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Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

Author

Listed:
  • Nicholas Collins

    (The University of Melbourne
    Peter Doherty Institute for Infection and Immunity, The University of Melbourne)

  • Xiaodong Jiang

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Ali Zaid

    (The University of Melbourne
    Peter Doherty Institute for Infection and Immunity, The University of Melbourne)

  • Bethany L. Macleod

    (The University of Melbourne
    Peter Doherty Institute for Infection and Immunity, The University of Melbourne)

  • Jane Li

    (The University of Melbourne
    Peter Doherty Institute for Infection and Immunity, The University of Melbourne)

  • Chang Ook Park

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Ashraful Haque

    (Malaria Immunology Laboratory, QIMR Berghofer Medical Research Institute and Australian Infectious Diseases Research Centre, The University of Queensland)

  • Sammy Bedoui

    (The University of Melbourne
    Peter Doherty Institute for Infection and Immunity, The University of Melbourne)

  • William R. Heath

    (The University of Melbourne
    Peter Doherty Institute for Infection and Immunity, The University of Melbourne)

  • Scott N. Mueller

    (The University of Melbourne
    Peter Doherty Institute for Infection and Immunity, The University of Melbourne)

  • Thomas S. Kupper

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Thomas Gebhardt

    (The University of Melbourne
    Peter Doherty Institute for Infection and Immunity, The University of Melbourne)

  • Francis R. Carbone

    (The University of Melbourne
    Peter Doherty Institute for Infection and Immunity, The University of Melbourne)

Abstract

Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4+ T cells in mouse skin are in equilibrium with the circulation at steady state. These cells are dispersed throughout the inter-follicular regions of the dermis and form clusters with antigen presenting cells around hair follicles. After infection or administration of a contact sensitizing agent, there is a sustained increase in skin CD4+ T-cell content, which is confined to the clusters, with a concomitant CCL5-dependent increase in CD4+ T-cell recruitment. Skin CCL5 is derived from CD11b+ cells and CD8+ T cells, with the elimination of the latter decreasing CD4+ T-cell numbers. These results reveal a complex pattern of tissue-retention and equilibration for CD4+ memory T cells in skin, which is altered by infection and inflammation history.

Suggested Citation

  • Nicholas Collins & Xiaodong Jiang & Ali Zaid & Bethany L. Macleod & Jane Li & Chang Ook Park & Ashraful Haque & Sammy Bedoui & William R. Heath & Scott N. Mueller & Thomas S. Kupper & Thomas Gebhardt , 2016. "Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation," Nature Communications, Nature, vol. 7(1), pages 1-13, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11514
    DOI: 10.1038/ncomms11514
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