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Dchs1–Fat4 regulation of polarized cell behaviours during skeletal morphogenesis

Author

Listed:
  • Yaopan Mao

    (Howard Hughes Medical Institute, Rutgers The State University of New Jersey)

  • Anna Kuta

    (King’s College London, Dental Institute)

  • Ivan Crespo-Enriquez

    (King’s College London, Dental Institute)

  • Danielle Whiting

    (King’s College London, Dental Institute)

  • Tina Martin

    (King’s College London, Dental Institute)

  • Joanna Mulvaney

    (King’s College London, Dental Institute)

  • Kenneth D. Irvine

    (Howard Hughes Medical Institute, Rutgers The State University of New Jersey)

  • Philippa Francis-West

    (King’s College London, Dental Institute)

Abstract

Skeletal shape varies widely across species as adaptation to specialized modes of feeding and locomotion, but how skeletal shape is established is unknown. An example of extreme diversity in the shape of a skeletal structure can be seen in the sternum, which varies considerably across species. Here we show that the Dchs1–Fat4 planar cell polarity pathway controls cell orientation in the early skeletal condensation to define the shape and relative dimensions of the mouse sternum. These changes fit a model of cell intercalation along differential Dchs1–Fat4 activity that drives a simultaneous narrowing, thickening and elongation of the sternum. Our results identify the regulation of cellular polarity within the early pre-chondrogenic mesenchyme, when skeletal shape is established, and provide the first demonstration that Fat4 and Dchs1 establish polarized cell behaviour intrinsically within the mesenchyme. Our data also reveal the first indication that cell intercalation processes occur during ventral body wall elongation and closure.

Suggested Citation

  • Yaopan Mao & Anna Kuta & Ivan Crespo-Enriquez & Danielle Whiting & Tina Martin & Joanna Mulvaney & Kenneth D. Irvine & Philippa Francis-West, 2016. "Dchs1–Fat4 regulation of polarized cell behaviours during skeletal morphogenesis," Nature Communications, Nature, vol. 7(1), pages 1-10, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11469
    DOI: 10.1038/ncomms11469
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    Cited by:

    1. Amrita Singh & Sameedha Thale & Tobias Leibner & Lucas Lamparter & Andrea Ricker & Harald Nüsse & Jürgen Klingauf & Milos Galic & Mario Ohlberger & Maja Matis, 2024. "Dynamic interplay of microtubule and actomyosin forces drive tissue extension," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Johann-Christoph Jann & Maximilian Mossner & Vladimir Riabov & Eva Altrock & Nanni Schmitt & Johanna Flach & Qingyu Xu & Verena Nowak & Julia Obländer & Iris Palme & Nadine Weimer & Alexander Streuer , 2021. "Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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