IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms11438.html
   My bibliography  Save this article

Host gene constraints and genomic context impact the expression and evolution of human microRNAs

Author

Listed:
  • Gustavo S. França

    (Centro de Oncologia Molecular, Hospital Sírio-Libanês, Rua Daher Cutait 69, 01308-060 São Paulo, Brazil
    Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil)

  • Maria D. Vibranovski

    (Universidade de São Paulo, Rua do Matao 277, 05508-090 São Paulo, Brazil)

  • Pedro A. F. Galante

    (Centro de Oncologia Molecular, Hospital Sírio-Libanês, Rua Daher Cutait 69, 01308-060 São Paulo, Brazil)

Abstract

Increasing evidence has shown that recent miRNAs tend to emerge within coding genes. Here we conjecture that human miRNA evolution is tightly influenced by the genomic context, especially by host genes. Our findings show a preferential emergence of intragenic miRNAs within old genes. We found that miRNAs within old host genes are significantly more broadly expressed than those within young ones. Young miRNAs within old genes are more broadly expressed than their intergenic counterparts, suggesting that young miRNAs have an initial advantage by residing in old genes, and benefit from their hosts’ expression control and from the exposure to diverse cellular contexts and target genes. Our results demonstrate that host genes may provide stronger expression constraints to intragenic miRNAs in the long run. We also report associated functional implications, highlighting the genomic context and host genes as driving factors for the expression and evolution of human miRNAs.

Suggested Citation

  • Gustavo S. França & Maria D. Vibranovski & Pedro A. F. Galante, 2016. "Host gene constraints and genomic context impact the expression and evolution of human microRNAs," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11438
    DOI: 10.1038/ncomms11438
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms11438
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms11438?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11438. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.