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Ultraflexible organic amplifier with biocompatible gel electrodes

Author

Listed:
  • Tsuyoshi Sekitani

    (The University of Tokyo
    The Institute of Scientific and Industrial Research, Osaka University)

  • Tomoyuki Yokota

    (The University of Tokyo)

  • Kazunori Kuribara

    (The University of Tokyo
    Present address: Flexible Electronics Research Center, Central 5, The National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305–856, Japan.)

  • Martin Kaltenbrunner

    (The University of Tokyo
    Soft Matter Physics, Linz Institute of Technology LIT, Johannes Kepler University Linz)

  • Takanori Fukushima

    (Chemical Resource Laboratory, Tokyo Institute of Technology)

  • Yusuke Inoue

    (The University of Tokyo)

  • Masaki Sekino

    (The University of Tokyo)

  • Takashi Isoyama

    (Graduate School of Medicine, The University of Tokyo)

  • Yusuke Abe

    (Graduate School of Medicine, The University of Tokyo)

  • Hiroshi Onodera

    (The University of Tokyo
    Photon Science Center, The University of Tokyo)

  • Takao Someya

    (The University of Tokyo
    The University of Tokyo
    Photon Science Center, The University of Tokyo)

Abstract

In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel composite exhibits admittance of 100 mS cm−2 and maintains high admittance even in a low-frequency range. On implantation into a living hypodermal tissue for 4 weeks, it showed a small foreign-body reaction compared with widely used metal electrodes. Capitalizing on the multi-functional gel composite, we fabricated an ultrathin and mechanically flexible organic active matrix amplifier on a 1.2-μm-thick polyethylene-naphthalate film to amplify (amplification factor: ∼200) weak biosignals. The composite was integrated to the amplifier to realize a direct lead epicardial electrocardiography that is easily spread over an uneven heart tissue.

Suggested Citation

  • Tsuyoshi Sekitani & Tomoyuki Yokota & Kazunori Kuribara & Martin Kaltenbrunner & Takanori Fukushima & Yusuke Inoue & Masaki Sekino & Takashi Isoyama & Yusuke Abe & Hiroshi Onodera & Takao Someya, 2016. "Ultraflexible organic amplifier with biocompatible gel electrodes," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11425
    DOI: 10.1038/ncomms11425
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