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Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks

Author

Listed:
  • J. Antonio González

    (The Francis Crick Institute, Mill Hill Laboratory)

  • Panagiota Iordanidou

    (The Francis Crick Institute, Mill Hill Laboratory)

  • Molly Strom

    (MRC NIMR
    Sainsbury Wellcome Centre, UCL)

  • Antoine Adamantidis

    (University of Bern, Bern University Hospital)

  • Denis Burdakov

    (The Francis Crick Institute, Mill Hill Laboratory
    King’s College London)

Abstract

The lateral hypothalamus (LH) controls energy balance. LH melanin-concentrating-hormone (MCH) and orexin/hypocretin (OH) neurons mediate energy accumulation and expenditure, respectively. MCH cells promote memory and appropriate stimulus-reward associations; their inactivation disrupts energy-optimal behaviour and causes weight loss. However, MCH cell dynamics during wakefulness are unknown, leaving it unclear if they differentially participate in brain activity during sensory processing. By fiberoptic recordings from molecularly defined populations of LH neurons in awake freely moving mice, we show that MCH neurons generate conditional population bursts. This MCH cell activity correlates with novelty exploration, is inhibited by stress and is inversely predicted by OH cell activity. Furthermore, we obtain brain-wide maps of monosynaptic inputs to MCH and OH cells, and demonstrate optogenetically that VGAT neurons in the amygdala and bed nucleus of stria terminalis inhibit MCH cells. These data reveal cell-type-specific LH dynamics during sensory integration, and identify direct neural controllers of MCH neurons.

Suggested Citation

  • J. Antonio González & Panagiota Iordanidou & Molly Strom & Antoine Adamantidis & Denis Burdakov, 2016. "Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks," Nature Communications, Nature, vol. 7(1), pages 1-9, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11395
    DOI: 10.1038/ncomms11395
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    Cited by:

    1. Han-Tao Li & Paulius Viskaitis & Eva Bracey & Daria Peleg-Raibstein & Denis Burdakov, 2024. "Transient targeting of hypothalamic orexin neurons alleviates seizures in a mouse model of epilepsy," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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