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Spontaneous formation and base pairing of plausible prebiotic nucleotides in water

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  • Brian J. Cafferty

    (School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive
    NSF-NASA Center for Chemical Evolution)

  • David M. Fialho

    (School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive
    NSF-NASA Center for Chemical Evolution)

  • Jaheda Khanam

    (School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive
    NSF-NASA Center for Chemical Evolution)

  • Ramanarayanan Krishnamurthy

    (NSF-NASA Center for Chemical Evolution
    The Scripps Research Institute)

  • Nicholas V. Hud

    (School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive
    NSF-NASA Center for Chemical Evolution)

Abstract

The RNA World hypothesis presupposes that abiotic reactions originally produced nucleotides, the monomers of RNA and universal constituents of metabolism. However, compatible prebiotic reactions for the synthesis of complementary (that is, base pairing) nucleotides and mechanisms for their mutual selection within a complex chemical environment have not been reported. Here we show that two plausible prebiotic heterocycles, melamine and barbituric acid, form glycosidic linkages with ribose and ribose-5-phosphate in water to produce nucleosides and nucleotides in good yields. Even without purification, these nucleotides base pair in aqueous solution to create linear supramolecular assemblies containing thousands of ordered nucleotides. Nucleotide anomerization and supramolecular assemblies favour the biologically relevant β-anomer form of these ribonucleotides, revealing abiotic mechanisms by which nucleotide structure and configuration could have been originally favoured. These findings indicate that nucleotide formation and selection may have been robust processes on the prebiotic Earth, if other nucleobases preceded those of extant life.

Suggested Citation

  • Brian J. Cafferty & David M. Fialho & Jaheda Khanam & Ramanarayanan Krishnamurthy & Nicholas V. Hud, 2016. "Spontaneous formation and base pairing of plausible prebiotic nucleotides in water," Nature Communications, Nature, vol. 7(1), pages 1-8, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11328
    DOI: 10.1038/ncomms11328
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    Cited by:

    1. Jibin Abraham Punnoose & Kevin J. Thomas & Arun Richard Chandrasekaran & Javier Vilcapoma & Andrew Hayden & Kacey Kilpatrick & Sweta Vangaveti & Alan Chen & Thomas Banco & Ken Halvorsen, 2023. "High-throughput single-molecule quantification of individual base stacking energies in nucleic acids," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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