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Low excitatory innervation balances high intrinsic excitability of immature dentate neurons

Author

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  • Cristina V. Dieni

    (University of Alabama at Birmingham
    Section of Physiology and Biochemistry, University of Perugia)

  • Roberto Panichi

    (Section of Physiology and Biochemistry, University of Perugia)

  • James B. Aimone

    (Sandia National Laboratories)

  • Chay T. Kuo

    (Duke University School of Medicine)

  • Jacques I. Wadiche

    (University of Alabama at Birmingham)

  • Linda Overstreet-Wadiche

    (University of Alabama at Birmingham)

Abstract

Persistent neurogenesis in the dentate gyrus produces immature neurons with high intrinsic excitability and low levels of inhibition that are predicted to be more broadly responsive to afferent activity than mature neurons. Mounting evidence suggests that these immature neurons are necessary for generating distinct neural representations of similar contexts, but it is unclear how broadly responsive neurons help distinguish between similar patterns of afferent activity. Here we show that stimulation of the entorhinal cortex in mouse brain slices paradoxically generates spiking of mature neurons in the absence of immature neuron spiking. Immature neurons with high intrinsic excitability fail to spike due to insufficient excitatory drive that results from low innervation rather than silent synapses or low release probability. Our results suggest that low synaptic connectivity prevents immature neurons from responding broadly to cortical activity, potentially enabling excitable immature neurons to contribute to sparse and orthogonal dentate representations.

Suggested Citation

  • Cristina V. Dieni & Roberto Panichi & James B. Aimone & Chay T. Kuo & Jacques I. Wadiche & Linda Overstreet-Wadiche, 2016. "Low excitatory innervation balances high intrinsic excitability of immature dentate neurons," Nature Communications, Nature, vol. 7(1), pages 1-13, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11313
    DOI: 10.1038/ncomms11313
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