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A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

Author

Listed:
  • Nathan Orr

    (Toronto General Research Institute, University Health Network)

  • Rima Arnaout

    (University of California San Francisco
    University of California San Francisco)

  • Lorne J. Gula

    (University Hospital, Western University)

  • Danna A. Spears

    (Toronto General Hospital, University Health Network)

  • Peter Leong-Sit

    (University Hospital, Western University)

  • Qiuju Li

    (Toronto General Research Institute, University Health Network)

  • Wadea Tarhuni

    (University Hospital, Western University)

  • Sven Reischauer

    (University of California San Francisco
    Max Planck Institute for Heart and Lung Research)

  • Vijay S. Chauhan

    (Toronto General Hospital, University Health Network)

  • Matthew Borkovich

    (Toronto General Hospital, University Health Network)

  • Shaheen Uppal

    (Toronto General Hospital, University Health Network)

  • Arnon Adler

    (Toronto General Hospital, University Health Network)

  • Shaun R. Coughlin

    (University of California San Francisco)

  • Didier Y. R. Stainier

    (University of California San Francisco
    University of California San Francisco
    Max Planck Institute for Heart and Lung Research)

  • Michael H. Gollob

    (Toronto General Research Institute, University Health Network
    Toronto General Hospital, University Health Network
    Peter Munk Cardiac Centre, University Health Network, University of Toronto)

Abstract

Atrial fibrillation (AF), the most common arrhythmia, is a growing epidemic with substantial morbidity and economic burden. Mechanisms underlying vulnerability to AF remain poorly understood, which contributes to the current lack of highly effective therapies. Recognizing mechanistic subtypes of AF may guide an individualized approach to patient management. Here, we describe a family with a previously unreported syndrome characterized by early-onset AF (age

Suggested Citation

  • Nathan Orr & Rima Arnaout & Lorne J. Gula & Danna A. Spears & Peter Leong-Sit & Qiuju Li & Wadea Tarhuni & Sven Reischauer & Vijay S. Chauhan & Matthew Borkovich & Shaheen Uppal & Arnon Adler & Shaun , 2016. "A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation," Nature Communications, Nature, vol. 7(1), pages 1-8, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11303
    DOI: 10.1038/ncomms11303
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