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Viscoelastic lithography for fabricating self-organizing soft micro-honeycomb structures with ultra-high aspect ratios

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  • Gi Seok Jeong

    (College of Health Science, Korea University
    Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center)

  • Da Yoon No

    (College of Health Science, Korea University
    School of Engineering and Medicine, Stanford University)

  • JaeSeo Lee

    (KU-KIST Graduate School of Converging Science and Technology, Korea University)

  • Junghyo Yoon

    (School of Mechanical Engineering, Korea University)

  • Seok Chung

    (School of Mechanical Engineering, Korea University)

  • Sang-Hoon Lee

    (College of Health Science, Korea University
    KU-KIST Graduate School of Converging Science and Technology, Korea University)

Abstract

High-aspect ratio micro- and nano-structures have been used for the production of a variety of applications. In this paper, we describe a simple and cost-effective approach to fabricate an arrayed microarchitecture with an ultra-high aspect ratio using soft materials. The shapes and sizes of the honeycomb structure can be easily modulated by changing the dimensions and position of the base mould pattern and the pressure. The honeycomb structure is used to prepare a drug delivery patch and a microwell array to form cell spheroids without cell loss. The honeycomb structures prepared using natural ECM (collagen–Matrigel) materials are successfully fabricated. The hepatocytes and endothelial cells are seeded and co-cultured in the ECM-based micro-honeycomb to prepare a 3D liver model successfully mimicking an ultrastructure of liver and providing enhanced liver function.

Suggested Citation

  • Gi Seok Jeong & Da Yoon No & JaeSeo Lee & Junghyo Yoon & Seok Chung & Sang-Hoon Lee, 2016. "Viscoelastic lithography for fabricating self-organizing soft micro-honeycomb structures with ultra-high aspect ratios," Nature Communications, Nature, vol. 7(1), pages 1-9, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11269
    DOI: 10.1038/ncomms11269
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