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Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy

Author

Listed:
  • Yiming Zhao

    (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai)

  • François Fay

    (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai)

  • Sjoerd Hak

    (The Norwegian University of Science and Technology)

  • Jose Manuel Perez-Aguilar

    (Weill Cornell Medical College of Cornell University
    IBM Thomas J. Watson Research Center)

  • Brenda L. Sanchez-Gaytan

    (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai)

  • Brandon Goode

    (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai)

  • Raphaël Duivenvoorden

    (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai
    Academic Medical Center)

  • Catharina de Lange Davies

    (The Norwegian University of Science and Technology)

  • Astrid Bjørkøy

    (The Norwegian University of Science and Technology)

  • Harel Weinstein

    (Weill Cornell Medical College of Cornell University
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University)

  • Zahi A. Fayad

    (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai)

  • Carlos Pérez-Medina

    (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai)

  • Willem J. M. Mulder

    (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai
    Academic Medical Center)

Abstract

A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug–carrier association after intravenous administration is essential for efficient drug delivery to the tumour. However, a large number of currently available nanocarriers are self-assembled nanoparticles whose drug-loading stability is critically affected by the in vivo environment. Here we used in vivo FRET imaging to systematically investigate how drug–carrier compatibility affects drug release in a tumour mouse model. We found the drug’s hydrophobicity and miscibility with the nanoparticles are two independent key parameters that determine its accumulation in the tumour. Next, we applied these findings to improve chemotherapeutic delivery by augmenting the parent drug’s compatibility; as a result, we achieved better antitumour efficacy. Our results help elucidate nanomedicines’ in vivo fate and provide guidelines for efficient drug delivery.

Suggested Citation

  • Yiming Zhao & François Fay & Sjoerd Hak & Jose Manuel Perez-Aguilar & Brenda L. Sanchez-Gaytan & Brandon Goode & Raphaël Duivenvoorden & Catharina de Lange Davies & Astrid Bjørkøy & Harel Weinstein & , 2016. "Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11221
    DOI: 10.1038/ncomms11221
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