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FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth

Author

Listed:
  • Felipe Slebe

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Federico Rojo

    (Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)
    IIS-Fundación Jimenez Diaz)

  • Maria Vinaixa

    (Centre for Omic Sciences, Universitat Rovira i Virgili
    Universitat Rovira i Virgili
    Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM))

  • Mar García-Rocha

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Giorgia Testoni

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Marc Guiu

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Evarist Planet

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Sara Samino

    (Centre for Omic Sciences, Universitat Rovira i Virgili
    Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM))

  • Enrique J. Arenas

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Antoni Beltran

    (Centre for Omic Sciences, Universitat Rovira i Virgili
    Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM))

  • Ana Rovira

    (Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)
    Medical Oncology Service, Hospital del Mar)

  • Ana Lluch

    (Medical Oncology Service, Hospital Clinico)

  • Xavier Salvatella

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

  • Oscar Yanes

    (Centre for Omic Sciences, Universitat Rovira i Virgili
    Universitat Rovira i Virgili
    Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM))

  • Joan Albanell

    (Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)
    Medical Oncology Service, Hospital del Mar
    Universitat Pompeu Fabra)

  • Joan J. Guinovart

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM)
    Universitat de Barcelona)

  • Roger R. Gomis

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

Abstract

The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids.

Suggested Citation

  • Felipe Slebe & Federico Rojo & Maria Vinaixa & Mar García-Rocha & Giorgia Testoni & Marc Guiu & Evarist Planet & Sara Samino & Enrique J. Arenas & Antoni Beltran & Ana Rovira & Ana Lluch & Xavier Salv, 2016. "FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11199
    DOI: 10.1038/ncomms11199
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    Cited by:

    1. Balkrishna Chaube & Kathryn M. Citrin & Mahnaz Sahraei & Abhishek K. Singh & Diego Saenz Urturi & Wen Ding & Richard W. Pierce & Raaisa Raaisa & Rebecca Cardone & Richard Kibbey & Carlos Fernández-Her, 2023. "Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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