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Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling

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  • Jose Maria Carvajal-Gonzalez

    (Tisch Cancer Institute, and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
    Present address: Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Badajoz 06071, Spain.)

  • Angel-Carlos Roman

    (Champalimaud Neuroscience Programme)

  • Marek Mlodzik

    (Tisch Cancer Institute, and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai)

Abstract

Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular orientation during development. An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole/cilia positioning, a function that has not been associated with PCP in Drosophila. Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings. We show that centrioles are polarized in pupal wing cells as a readout of PCP signalling, with both gain and loss-of-function Fz/PCP signalling affecting centriole polarization. Importantly, loss or gain of centrioles does not affect Fz/PCP establishment, implicating centriolar positioning as a conserved PCP-readout, likely downstream of PCP-regulated actin polymerization. Together with vertebrate data, these results suggest a unifying model of centriole/cilia positioning as a common downstream effect of PCP signalling from flies to mammals.

Suggested Citation

  • Jose Maria Carvajal-Gonzalez & Angel-Carlos Roman & Marek Mlodzik, 2016. "Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling," Nature Communications, Nature, vol. 7(1), pages 1-9, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11135
    DOI: 10.1038/ncomms11135
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    Cited by:

    1. Maria Jussila & Curtis W. Boswell & Nigel W. Griffiths & Patrick G. Pumputis & Brian Ciruna, 2022. "Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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