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ZBTB20 is required for anterior pituitary development and lactotrope specification

Author

Listed:
  • Dongmei Cao

    (Second Military Medical University)

  • Xianhua Ma

    (Second Military Medical University)

  • Jiao Cai

    (Second Military Medical University)

  • Jing Luan

    (Second Military Medical University
    Dalian Medical University, 9 West Section)

  • An-Jun Liu

    (Second Military Medical University
    Second Military Medical University)

  • Rui Yang

    (Second Military Medical University)

  • Yi Cao

    (Second Military Medical University
    Changhai Hospital)

  • Xiaotong Zhu

    (Second Military Medical University
    Dalian Medical University, 9 West Section)

  • Hai Zhang

    (Second Military Medical University)

  • Yu-Xia Chen

    (Second Military Medical University)

  • Yuguang Shi

    (Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio)

  • Guang-Xia Shi

    (Dalian Medical University, 9 West Section)

  • Dajin Zou

    (Changhai Hospital)

  • Xuetao Cao

    (Chinese Academy of Medical Sciences)

  • Michael J. Grusby

    (Harvard School of Public Health)

  • Zhifang Xie

    (Second Military Medical University
    Second Military Medical University)

  • Weiping J. Zhang

    (Second Military Medical University)

Abstract

The anterior pituitary harbours five distinct hormone-producing cell types, and their cellular differentiation is a highly regulated and coordinated process. Here we show that ZBTB20 is essential for anterior pituitary development and lactotrope specification in mice. In anterior pituitary, ZBTB20 is highly expressed by all the mature endocrine cell types, and to some less extent by somatolactotropes, the precursors of prolactin (PRL)-producing lactotropes. Disruption of Zbtb20 leads to anterior pituitary hypoplasia, hypopituitary dwarfism and a complete loss of mature lactotropes. In ZBTB20-null mice, although lactotrope lineage commitment is normally initiated, somatolactotropes exhibit profound defects in lineage specification and expansion. Furthermore, endogenous ZBTB20 protein binds to Prl promoter, and its knockdown decreases PRL expression and secretion in a lactotrope cell line MMQ. In addition, ZBTB20 overexpression enhances the transcriptional activity of Prl promoter in vitro. In conclusion, our findings point to ZBTB20 as a critical regulator of anterior pituitary development and lactotrope specification.

Suggested Citation

  • Dongmei Cao & Xianhua Ma & Jiao Cai & Jing Luan & An-Jun Liu & Rui Yang & Yi Cao & Xiaotong Zhu & Hai Zhang & Yu-Xia Chen & Yuguang Shi & Guang-Xia Shi & Dajin Zou & Xuetao Cao & Michael J. Grusby & Z, 2016. "ZBTB20 is required for anterior pituitary development and lactotrope specification," Nature Communications, Nature, vol. 7(1), pages 1-13, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11121
    DOI: 10.1038/ncomms11121
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    Cited by:

    1. Jian-Hui Shi & Yu-Xia Chen & Yingying Feng & Xiaohang Yang & Jie Lin & Ting Wang & Chun-Chun Wei & Xian-Hua Ma & Rui Yang & Dongmei Cao & Hai Zhang & Xiangyang Xie & Zhifang Xie & Weiping J. Zhang, 2023. "Fructose overconsumption impairs hepatic manganese homeostasis and ammonia disposal," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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