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Cortical contributions to the auditory frequency-following response revealed by MEG

Author

Listed:
  • Emily B. J. Coffey

    (Montreal Neurological Institute, McGill University
    Centre for Research on Brain, Language and Music (CRBLM)
    International Laboratory for Brain, Music, and Sound Research (BRAMS))

  • Sibylle C. Herholz

    (Montreal Neurological Institute, McGill University
    Centre for Research on Brain, Language and Music (CRBLM)
    International Laboratory for Brain, Music, and Sound Research (BRAMS)
    German Center for Neurodegenerative Diseases (DZNE))

  • Alexander M. P. Chepesiuk

    (Montreal Neurological Institute, McGill University)

  • Sylvain Baillet

    (Montreal Neurological Institute, McGill University
    Centre for Research on Brain, Language and Music (CRBLM))

  • Robert J. Zatorre

    (Montreal Neurological Institute, McGill University
    Centre for Research on Brain, Language and Music (CRBLM)
    International Laboratory for Brain, Music, and Sound Research (BRAMS))

Abstract

The auditory frequency-following response (FFR) to complex periodic sounds is used to study the subcortical auditory system, and has been proposed as a biomarker for disorders that feature abnormal sound processing. Despite its value in fundamental and clinical research, the neural origins of the FFR are unclear. Using magnetoencephalography, we observe a strong, right-asymmetric contribution to the FFR from the human auditory cortex at the fundamental frequency of the stimulus, in addition to signal from cochlear nucleus, inferior colliculus and medial geniculate. This finding is highly relevant for our understanding of plasticity and pathology in the auditory system, as well as higher-level cognition such as speech and music processing. It suggests that previous interpretations of the FFR may need re-examination using methods that allow for source separation.

Suggested Citation

  • Emily B. J. Coffey & Sibylle C. Herholz & Alexander M. P. Chepesiuk & Sylvain Baillet & Robert J. Zatorre, 2016. "Cortical contributions to the auditory frequency-following response revealed by MEG," Nature Communications, Nature, vol. 7(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11070
    DOI: 10.1038/ncomms11070
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