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Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning

Author

Listed:
  • Serra E. Favila

    (New York University)

  • Avi J. H. Chanales

    (New York University)

  • Brice A. Kuhl

    (New York University
    University of Oregon)

Abstract

The hippocampus is believed to reduce memory interference by disambiguating neural representations of similar events. However, there is limited empirical evidence linking representational overlap in the hippocampus to memory interference. Likewise, it is not fully understood how learning influences overlap among hippocampal representations. Using pattern-based fMRI analyses, we tested for a bidirectional relationship between memory overlap in the human hippocampus and learning. First, we show that learning drives hippocampal representations of similar events apart from one another. These changes are not explained by task demands to discriminate similar stimuli and are fully absent in visual cortical areas that feed into the hippocampus. Second, we show that lower representational overlap in the hippocampus benefits subsequent learning by preventing interference between similar memories. These findings reveal targeted experience-dependent changes in hippocampal representations of similar events and provide a critical link between memory overlap in the hippocampus and behavioural expressions of memory interference.

Suggested Citation

  • Serra E. Favila & Avi J. H. Chanales & Brice A. Kuhl, 2016. "Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning," Nature Communications, Nature, vol. 7(1), pages 1-10, April.
  • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11066
    DOI: 10.1038/ncomms11066
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    Cited by:

    1. Jacob L. S. Bellmund & Lorena Deuker & Nicole D. Montijn & Christian F. Doeller, 2022. "Mnemonic construction and representation of temporal structure in the hippocampal formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Yann Vanrobaeys & Utsav Mukherjee & Lucy Langmack & Stacy E. Beyer & Ethan Bahl & Li-Chun Lin & Jacob J. Michaelson & Ted Abel & Snehajyoti Chatterjee, 2023. "Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Li Zheng & Zhiyao Gao & Andrew S. McAvan & Eve A. Isham & Arne D. Ekstrom, 2021. "Partially overlapping spatial environments trigger reinstatement in hippocampus and schema representations in prefrontal cortex," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Jin Li & Dan Cao & Shan Yu & Xinyu Xiao & Lukas Imbach & Lennart Stieglitz & Johannes Sarnthein & Tianzi Jiang, 2023. "Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    5. Sam Audrain & Mary Pat McAndrews, 2022. "Schemas provide a scaffold for neocortical integration of new memories over time," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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