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FoxO1-mediated autophagy is required for NK cell development and innate immunity

Author

Listed:
  • Shuo Wang

    (CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences)

  • Pengyan Xia

    (CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences)

  • Guanling Huang

    (CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences)

  • Pingping Zhu

    (CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences)

  • Jing Liu

    (CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences)

  • Buqing Ye

    (CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences)

  • Ying Du

    (CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences)

  • Zusen Fan

    (CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences)

Abstract

Natural killer (NK) cells exert a crucial role in early immune responses as a major innate effector component. However, the underlying mechanisms of NK cell development remain largely elusive. Here we show that robust autophagy appears in the stage of immature NK cells (iNKs), which is required for NK cell development. Autophagy defects result in damaged mitochondria and accumulation of reactive oxygen species (ROS) that leads to apoptosis of NK cells. Autophagy protects NK cell viability during development through removal of damaged mitochondria and intracellular ROS. Phosphorylated Forkhead box O (FoxO)1 is located to the cytoplasm of iNKs and interacts with Atg7, leading to induction of autophagy. FoxO1 deficiency or an inactive FoxO1AAA mutant abrogates autophagy initiation in iNKs and impairs NK cell development and viral clearance. Therefore we conclude that FoxO1-mediated autophagy is required for NK cell development and NK cell-induced innate immunity.

Suggested Citation

  • Shuo Wang & Pengyan Xia & Guanling Huang & Pingping Zhu & Jing Liu & Buqing Ye & Ying Du & Zusen Fan, 2016. "FoxO1-mediated autophagy is required for NK cell development and innate immunity," Nature Communications, Nature, vol. 7(1), pages 1-15, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11023
    DOI: 10.1038/ncomms11023
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    Cited by:

    1. Federica Portale & Roberta Carriero & Marta Iovino & Paolo Kunderfranco & Marta Pandini & Giulia Marelli & Nicolò Morina & Massimo Lazzeri & Paolo Casale & Piergiuseppe Colombo & Gabriele Simone & Chi, 2024. "C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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