IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms10933.html
   My bibliography  Save this article

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Author

Listed:
  • Sonja I. Berndt

    (National Cancer Institute)

  • Nicola J. Camp

    (Huntsman Cancer Institute and University of Utah School of Medicine)

  • Christine F. Skibola

    (School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
    University of California Berkeley School of Public Health)

  • Joseph Vijai

    (Memorial Sloan Kettering Cancer Center)

  • Zhaoming Wang

    (Cancer Genomics Research Laboratory, National Cancer Institute)

  • Jian Gu

    (MD Anderson Cancer Center)

  • Alexandra Nieters

    (Center for Chronic Immunodeficiency, University Medical Center Freiburg)

  • Rachel S. Kelly

    (Harvard School of Public Health
    MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London)

  • Karin E. Smedby

    (Solna, Karolinska Institutet, Karolinska University Hospital)

  • Alain Monnereau

    (Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)
    Université Paris Descartes
    Registre des hémopathies malignes de la Gironde, Institut Bergonié)

  • Wendy Cozen

    (USC Keck School of Medicine, University of Southern California
    Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California)

  • Angela Cox

    (University of Sheffield)

  • Sophia S. Wang

    (City of Hope Beckman Research Institute)

  • Qing Lan

    (National Cancer Institute)

  • Lauren R. Teras

    (Epidemiology Research Program, American Cancer Society)

  • Moara Machado

    (National Cancer Institute
    Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais)

  • Meredith Yeager

    (Cancer Genomics Research Laboratory, National Cancer Institute)

  • Angela R. Brooks-Wilson

    (Genome Sciences Centre, BC Cancer Agency
    Simon Fraser University)

  • Patricia Hartge

    (National Cancer Institute)

  • Mark P. Purdue

    (Ontario Health Study)

  • Brenda M. Birmann

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Claire M. Vajdic

    (Centre for Big Data Research in Health, University of New South Wales)

  • Pierluigi Cocco

    (Clinical and Molecular Medicine, University of Cagliari)

  • Yawei Zhang

    (Yale School of Public Health)

  • Graham G. Giles

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne)

  • Anne Zeleniuch-Jacquotte

    (New York University School of Medicine
    New York University School of Medicine
    Perlmutter Cancer Center, NYU Langone Medical Center)

  • Charles Lawrence

    (Westat)

  • Rebecca Montalvan

    (Westat)

  • Laurie Burdett

    (Cancer Genomics Research Laboratory, National Cancer Institute)

  • Amy Hutchinson

    (Cancer Genomics Research Laboratory, National Cancer Institute)

  • Yuanqing Ye

    (MD Anderson Cancer Center)

  • Timothy G. Call

    (Mayo Clinic)

  • Tait D. Shanafelt

    (Mayo Clinic)

  • Anne J. Novak

    (Mayo Clinic)

  • Neil E. Kay

    (Mayo Clinic)

  • Mark Liebow

    (Mayo Clinic)

  • Julie M. Cunningham

    (Mayo Clinic)

  • Cristine Allmer

    (Mayo Clinic)

  • Henrik Hjalgrim

    (Statens Serum Institut)

  • Hans-Olov Adami

    (Harvard School of Public Health
    Karolinska Institutet)

  • Mads Melbye

    (Statens Serum Institut
    Stanford University School of Medicine)

  • Bengt Glimelius

    (Genetics and Pathology, Uppsala University)

  • Ellen T. Chang

    (Center for Epidemiology and Computational Biology, Health Sciences, Exponent, Inc.
    Stanford University School of Medicine)

  • Martha Glenn

    (Huntsman Cancer Institute)

  • Karen Curtin

    (University of Utah School of Medicine)

  • Lisa A. Cannon-Albright

    (University of Utah School of Medicine
    George E. Wahlen Department of Veterans Affairs Medical Center)

  • W Ryan Diver

    (Epidemiology Research Program, American Cancer Society)

  • Brian K. Link

    (Carver College of Medicine, The University of Iowa)

  • George J. Weiner

    (Carver College of Medicine, The University of Iowa)

  • Lucia Conde

    (School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
    University of California Berkeley School of Public Health)

  • Paige M. Bracci

    (University of California San Francisco)

  • Jacques Riby

    (School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
    University of California Berkeley School of Public Health)

  • Donna K. Arnett

    (School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham)

  • Degui Zhi

    (University of Alabama at Birmingham)

  • Justin M. Leach

    (University of Alabama at Birmingham)

  • Elizabeth A. Holly

    (University of California San Francisco)

  • Rebecca D. Jackson

    (Diabetes and Metabolism, The Ohio State University)

  • Lesley F. Tinker

    (Fred Hutchinson Cancer Research Center)

  • Yolanda Benavente

    (Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
    CIBER de Epidemiología y Salud Pública (CIBERESP))

  • Núria Sala

    (Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
    Translational Research Laboratory, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat)

  • Delphine Casabonne

    (Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL, 08908L’Hospitalet de Llobregat
    CIBER Epidemiología y Salud Pública (CIBERESP))

  • Nikolaus Becker

    (German Cancer Research Center (DKFZ))

  • Paolo Boffetta

    (The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai)

  • Paul Brennan

    (International Agency for Research on Cancer (IARC))

  • Lenka Foretova

    (Masaryk Memorial Cancer Institute and MF MU)

  • Marc Maynadie

    (EA 4184, Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University Hospital)

  • James McKay

    (International Agency for Research on Cancer (IARC))

  • Anthony Staines

    (School of Nursing and Human Sciences, Dublin City University)

  • Kari G. Chaffee

    (Mayo Clinic)

  • Sara J. Achenbach

    (Mayo Clinic)

  • Celine M. Vachon

    (Mayo Clinic)

  • Lynn R. Goldin

    (National Cancer Institute)

  • Sara S. Strom

    (MD Anderson Cancer Center)

  • Jose F. Leis

    (Mayo Clinic)

  • J. Brice Weinberg

    (Duke University and VA Medical Centers)

  • Neil E. Caporaso

    (National Cancer Institute)

  • Aaron D. Norman

    (Mayo Clinic)

  • Anneclaire J. De Roos

    (Fred Hutchinson Cancer Research Center
    Drexel University School of Public Health)

  • Lindsay M. Morton

    (National Cancer Institute)

  • Richard K. Severson

    (Wayne State University)

  • Elio Riboli

    (School of Public Health, Imperial College London)

  • Paolo Vineis

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
    Human Genetics Foundation)

  • Rudolph Kaaks

    (German Cancer Research Center (DKFZ))

  • Giovanna Masala

    (Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO))

  • Elisabete Weiderpass

    (Karolinska Institutet
    Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway
    Cancer Registry of Norway, Institute of Population-Based Cancer Research
    Genetic Epidemiology Group, Folkhälsan Research Center)

  • María- Dolores Chirlaque

    (CIBER de Epidemiología y Salud Pública (CIBERESP)
    Murcia Regional Health Authority)

  • Roel C. H. Vermeulen

    (Institute for Risk Assessment Sciences, Utrecht University
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht)

  • Ruth C. Travis

    (Cancer Epidemiology Unit, University of Oxford)

  • Melissa C. Southey

    (Genetic Epidemiology Laboratory, University of Melbourne)

  • Roger L. Milne

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne)

  • Demetrius Albanes

    (National Cancer Institute)

  • Jarmo Virtamo

    (Chronic Disease Prevention Unit, National Institute for Health and Welfare)

  • Stephanie Weinstein

    (National Cancer Institute)

  • Jacqueline Clavel

    (Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)
    Université Paris Descartes)

  • Tongzhang Zheng

    (Yale School of Public Health)

  • Theodore R. Holford

    (Yale School of Public Health)

  • Danylo J. Villano

    (Memorial Sloan Kettering Cancer Center)

  • Ann Maria

    (Memorial Sloan Kettering Cancer Center)

  • John J. Spinelli

    (Cancer Control Research, BC Cancer Agency
    School of Population and Public Health, University of British Columbia)

  • Randy D. Gascoyne

    (Center for Lymphoid Cancer, BC Cancer Agency
    University of British Columbia)

  • Joseph M. Connors

    (Center for Lymphoid Cancer, BC Cancer Agency
    University of British Columbia)

  • Kimberly A. Bertrand

    (Harvard School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School)

  • Edward Giovannucci

    (Harvard School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health)

  • Peter Kraft

    (Harvard School of Public Health
    Harvard School of Public Health)

  • Anne Kricker

    (Sydney School of Public Health, The University of Sydney)

  • Jenny Turner

    (Faculty of Medicine and Health Sciences, Macquarie University
    Douglass Hanly Moir Pathology)

  • Maria Grazia Ennas

    (University of Cagliari)

  • Giovanni M. Ferri

    (University of Bari)

  • Lucia Miligi

    (Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO))

  • Liming Liang

    (Harvard School of Public Health
    Harvard School of Public Health)

  • Baoshan Ma

    (Harvard School of Public Health
    College of Information Science and Technology, Dalian Maritime University)

  • Jinyan Huang

    (Harvard School of Public Health)

  • Simon Crouch

    (University of York)

  • Ju-Hyun Park

    (Dongguk University)

  • Nilanjan Chatterjee

    (National Cancer Institute)

  • Kari E. North

    (University of North Carolina at Chapel Hill
    Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill)

  • John A. Snowden

    (University of Sheffield
    Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital)

  • Josh Wright

    (University of Sheffield
    Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital)

  • Joseph F. Fraumeni

    (National Cancer Institute)

  • Kenneth Offit

    (Memorial Sloan Kettering Cancer Center)

  • Xifeng Wu

    (MD Anderson Cancer Center)

  • Silvia de Sanjose

    (Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
    CIBER de Epidemiología y Salud Pública (CIBERESP))

  • James R. Cerhan

    (Mayo Clinic)

  • Stephen J. Chanock

    (National Cancer Institute)

  • Nathaniel Rothman

    (National Cancer Institute)

  • Susan L. Slager

    (Mayo Clinic)

Abstract

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10−11), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10−8) and 3q28 (rs9815073, LPP, P=3.62 × 10−8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10−11) in the combined analysis. We find suggestive evidence (P

Suggested Citation

  • Sonja I. Berndt & Nicola J. Camp & Christine F. Skibola & Joseph Vijai & Zhaoming Wang & Jian Gu & Alexandra Nieters & Rachel S. Kelly & Karin E. Smedby & Alain Monnereau & Wendy Cozen & Angela Cox & , 2016. "Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia," Nature Communications, Nature, vol. 7(1), pages 1-9, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10933
    DOI: 10.1038/ncomms10933
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms10933
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms10933?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10933. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.