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IL-17-producing γδ T cells enhance bone regeneration

Author

Listed:
  • Takehito Ono

    (Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)

  • Kazuo Okamoto

    (Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
    Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project)

  • Tomoki Nakashima

    (Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
    Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST)
    Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (AMED-CREST), Yushima 1-5-45, Bunkyo-ku)

  • Takeshi Nitta

    (Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)

  • Shohei Hori

    (Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Science)

  • Yoichiro Iwakura

    (Research Institute for Biological Sciences, Tokyo University of Science)

  • Hiroshi Takayanagi

    (Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
    Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project)

Abstract

Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing γδ T cells in skeletal tissue regeneration.

Suggested Citation

  • Takehito Ono & Kazuo Okamoto & Tomoki Nakashima & Takeshi Nitta & Shohei Hori & Yoichiro Iwakura & Hiroshi Takayanagi, 2016. "IL-17-producing γδ T cells enhance bone regeneration," Nature Communications, Nature, vol. 7(1), pages 1-9, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10928
    DOI: 10.1038/ncomms10928
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