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Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis

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  • Niklas Mattsson

    (Clinical Memory Research Unit, Lund University
    Memory Clinic, Skåne University Hospital
    Skåne University Hospital)

  • Philip S. Insel

    (Clinical Memory Research Unit, Lund University
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center (SFVAMC) campus, 4150 Clement Street, University of California)

  • Sebastian Palmqvist

    (Clinical Memory Research Unit, Lund University
    Skåne University Hospital)

  • Erik Stomrud

    (Clinical Memory Research Unit, Lund University
    Memory Clinic, Skåne University Hospital)

  • Danielle van Westen

    (Diagnostic Radiology, Lund University, Box 117
    Center for Medical Imaging and Physiology, Skåne University Hospital)

  • Lennart Minthon

    (Clinical Memory Research Unit, Lund University
    Memory Clinic, Skåne University Hospital)

  • Henrik Zetterberg

    (UCL Institute of Neurology, Queen Square
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg)

  • Kaj Blennow

    (Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg)

  • Oskar Hansson

    (Clinical Memory Research Unit, Lund University
    Memory Clinic, Skåne University Hospital)

Abstract

Increased APP (amyloid precursor protein) processing causes β-amyloid (Aβ) accumulation in autosomal dominant Alzheimer's disease (AD), but it is unclear if it also affects sporadic Aβ accumulation. We tested healthy controls and patients with mild cognitive symptoms (N=331) in the BioFINDER study, using cerebrospinal fluid (CSF) Aβ40 as a surrogate for amyloidogenic APP processing. We find that levels of brain Aβ fibrils (measured by 18F-flutemetamol PET) are independently associated with high CSF Aβ40 (P

Suggested Citation

  • Niklas Mattsson & Philip S. Insel & Sebastian Palmqvist & Erik Stomrud & Danielle van Westen & Lennart Minthon & Henrik Zetterberg & Kaj Blennow & Oskar Hansson, 2016. "Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis," Nature Communications, Nature, vol. 7(1), pages 1-7, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10918
    DOI: 10.1038/ncomms10918
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