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Cadherin-11 localizes to focal adhesions and promotes cell–substrate adhesion

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  • Rahul P. Langhe

    (Zoological Institute, Cell and Developmental Biology, Karlsruhe Institute of Technology (KIT)
    Present address: Institute of Neuroscience Paris-Saclay, UMR CNRS 9197, Université Paris-Sud, Orsay, France)

  • Tetyana Gudzenko

    (Center for Functional Nanostructures, Karlsruhe Institute of Technology (KIT))

  • Michael Bachmann

    (Zoological Institute, Cell and Neurobiology Biology, Karlsruhe Institute of Technology (KIT))

  • Sarah F. Becker

    (Zoological Institute, Cell and Developmental Biology, Karlsruhe Institute of Technology (KIT)
    Present address: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U964, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch Cu Strasbourg, France)

  • Carina Gonnermann

    (Center for Functional Nanostructures, Karlsruhe Institute of Technology (KIT))

  • Claudia Winter

    (Zoological Institute, Cell and Developmental Biology, Karlsruhe Institute of Technology (KIT))

  • Genevieve Abbruzzese

    (University of Massachusetts)

  • Dominique Alfandari

    (University of Massachusetts)

  • Marie-Claire Kratzer

    (Zoological Institute, Cell and Developmental Biology, Karlsruhe Institute of Technology (KIT)
    Laboratory for Applications of Synchrotron Radiation, Karlsruhe Institute of Technology (KIT))

  • Clemens M. Franz

    (Center for Functional Nanostructures, Karlsruhe Institute of Technology (KIT))

  • Jubin Kashef

    (Zoological Institute, Cell and Developmental Biology, Karlsruhe Institute of Technology (KIT)
    Institute for Photon Science and Synchrotron Radiation, Karlsruhe Institute of Technology (KIT))

Abstract

Cadherin receptors have a well-established role in cell–cell adhesion, cell polarization and differentiation. However, some cadherins also promote cell and tissue movement during embryonic development and tumour progression. In particular, cadherin-11 is upregulated during tumour and inflammatory cell invasion, but the mechanisms underlying cadherin-11 stimulated cell migration are still incompletely understood. Here, we show that cadherin-11 localizes to focal adhesions and promotes adhesion to fibronectin in Xenopus neural crest, a highly migratory embryonic cell population. Transfected cadherin-11 also localizes to focal adhesions in different mammalian cell lines, while endogenous cadherin-11 shows focal adhesion localization in primary human fibroblasts. In focal adhesions, cadherin-11 co-localizes with β1-integrin and paxillin and physically interacts with the fibronectin-binding proteoglycan syndecan-4. Adhesion to fibronectin mediated by cadherin-11/syndecan-4 complexes requires both the extracellular domain of syndecan-4, and the transmembrane and cytoplasmic domains of cadherin-11. These results reveal an unexpected role of a classical cadherin in cell–matrix adhesion during cell migration.

Suggested Citation

  • Rahul P. Langhe & Tetyana Gudzenko & Michael Bachmann & Sarah F. Becker & Carina Gonnermann & Claudia Winter & Genevieve Abbruzzese & Dominique Alfandari & Marie-Claire Kratzer & Clemens M. Franz & Ju, 2016. "Cadherin-11 localizes to focal adhesions and promotes cell–substrate adhesion," Nature Communications, Nature, vol. 7(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10909
    DOI: 10.1038/ncomms10909
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