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Cross-modal representations of first-hand and vicarious pain, disgust and fairness in insular and cingulate cortex

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  • Corrado Corradi-Dell’Acqua

    (Swiss Centre for Affective Sciences, University of Geneva
    Laboratory for Neurology and Imaging of Cognition, University Medical Center
    FPSE, University of Geneva, Campus Biotech, 9, Chemin des Mines, Geneva CH-1211, Switzerland)

  • Anita Tusche

    (Max Planck Institute for Human Cognitive and Brain Sciences
    Caltech Emotion and Social Cognition Laboratory, California Institute of Technology)

  • Patrik Vuilleumier

    (Swiss Centre for Affective Sciences, University of Geneva
    Laboratory for Neurology and Imaging of Cognition, University Medical Center)

  • Tania Singer

    (Max Planck Institute for Human Cognitive and Brain Sciences)

Abstract

The anterior insula (AI) and mid-anterior cingulate cortex (mACC) have repeatedly been implicated in first-hand and vicarious experiences of pain, disgust and unfairness. However, it is debated whether these regions process different aversive events through a common modality-independent code, reflecting the shared unpleasantness of the experiences or through independent modality-specific representations. Using functional magnetic resonance imaging, we subjected 19 participants (and 19 confederates) to equally unpleasant painful and disgusting stimulations, as well as unfair monetary treatments. Multivoxel pattern analysis identified modality-independent activation maps in the left AI and mACC, pointing to common coding of affective unpleasantness, but also response patterns specific for the events’ sensory properties and the person to whom it was addressed, particularly in the right AI. Our results provide evidence of both functional specialization and integration within AI and mACC, and support a comprehensive role of this network in processing aversive experiences for self and others.

Suggested Citation

  • Corrado Corradi-Dell’Acqua & Anita Tusche & Patrik Vuilleumier & Tania Singer, 2016. "Cross-modal representations of first-hand and vicarious pain, disgust and fairness in insular and cingulate cortex," Nature Communications, Nature, vol. 7(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10904
    DOI: 10.1038/ncomms10904
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    Cited by:

    1. Anita Tusche & Robert P. Spunt & Lynn K. Paul & Julian M. Tyszka & Ralph Adolphs, 2023. "Neural signatures of social inferences predict the number of real-life social contacts and autism severity," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Thomas Baumgartner & Anne Saulin & Grit Hein & Daria Knoch, 2016. "Structural Differences in Insular Cortex Reflect Vicarious Injustice Sensitivity," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-9, December.
    3. Marco Capasso & Alessio Moneta, 2016. "Macroeconomic responses to an independent monetary policy shock: a (more) agnostic identification procedure," LEM Papers Series 2016/36, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy.
    4. Kevin Riehl & Anastasios Kouvelas & Michail Makridis, 2024. "Towards fair roads -- Why we should & how to improve the fairness in traffic engineering," Papers 2408.01309, arXiv.org.
    5. Feng Zhou & Weihua Zhao & Ziyu Qi & Yayuan Geng & Shuxia Yao & Keith M. Kendrick & Tor D. Wager & Benjamin Becker, 2021. "A distributed fMRI-based signature for the subjective experience of fear," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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