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G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination

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  • Hyun-Jeong Yang

    (Weizmann Institute of Science)

  • Anna Vainshtein

    (Weizmann Institute of Science)

  • Galia Maik-Rachline

    (Weizmann Institute of Science)

  • Elior Peles

    (Weizmann Institute of Science)

Abstract

While the formation of myelin by oligodendrocytes is critical for the function of the central nervous system, the molecular mechanism controlling oligodendrocyte differentiation remains largely unknown. Here we identify G protein-coupled receptor 37 (GPR37) as an inhibitor of late-stage oligodendrocyte differentiation and myelination. GPR37 is enriched in oligodendrocytes and its expression increases during their differentiation into myelin forming cells. Genetic deletion of Gpr37 does not affect the number of oligodendrocyte precursor cells, but results in precocious oligodendrocyte differentiation and hypermyelination. The inhibition of oligodendrocyte differentiation by GPR37 is mediated by suppression of an exchange protein activated by cAMP (EPAC)-dependent activation of Raf-MAPK-ERK1/2 module and nuclear translocation of ERK1/2. Our data suggest that GPR37 regulates central nervous system myelination by controlling the transition from early-differentiated to mature oligodendrocytes.

Suggested Citation

  • Hyun-Jeong Yang & Anna Vainshtein & Galia Maik-Rachline & Elior Peles, 2016. "G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination," Nature Communications, Nature, vol. 7(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10884
    DOI: 10.1038/ncomms10884
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