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Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration

Author

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  • Seung-Yoon Park

    (School of Medicine, Dongguk University)

  • Youngeun Yun

    (School of Medicine, Kyungpook National University)

  • Jung-Suk Lim

    (School of Medicine, Dongguk University)

  • Mi-Jin Kim

    (School of Medicine, Dongguk University)

  • Sang-Yeob Kim

    (University of Ulsan, College of Medicine & Asan Institute for Life Sciences, Asan Medical Center)

  • Jung-Eun Kim

    (School of Medicine, Kyungpook National University)

  • In-San Kim

    (Biomedical Research Institute, Korea Institute Science and Technology
    KU-KIST school, Korea University)

Abstract

Myoblast fusion is essential for the formation of skeletal muscle myofibres. Studies have shown that phosphatidylserine is necessary for myoblast fusion, but the underlying mechanism is not known. Here we show that the phosphatidylserine receptor stabilin-2 acts as a membrane protein for myoblast fusion during myogenic differentiation and muscle regeneration. Stabilin-2 expression is induced during myogenic differentiation, and is regulated by calcineurin/NFAT signalling in myoblasts. Forced expression of stabilin-2 in myoblasts is associated with increased myotube formation, whereas deficiency of stabilin-2 results in the formation of small, thin myotubes. Stab2-deficient mice have myofibres with small cross-sectional area and few myonuclei and impaired muscle regeneration after injury. Importantly, myoblasts lacking stabilin-2 have reduced phosphatidylserine-dependent fusion. Collectively, our results show that stabilin-2 contributes to phosphatidylserine-dependent myoblast fusion and provide new insights into the molecular mechanism by which phosphatidylserine mediates myoblast fusion during muscle growth and regeneration.

Suggested Citation

  • Seung-Yoon Park & Youngeun Yun & Jung-Suk Lim & Mi-Jin Kim & Sang-Yeob Kim & Jung-Eun Kim & In-San Kim, 2016. "Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration," Nature Communications, Nature, vol. 7(1), pages 1-15, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10871
    DOI: 10.1038/ncomms10871
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    Cited by:

    1. Viviane Tran & Sarah Nahlé & Amélie Robert & Inès Desanlis & Ryan Killoran & Sophie Ehresmann & Marie-Pier Thibault & David Barford & Kodi S. Ravichandran & Martin Sauvageau & Matthew J. Smith & Marie, 2022. "Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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