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Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer

Author

Listed:
  • Dingxiao Zhang

    (University of Texas MD Anderson Cancer Center)

  • Daechan Park

    (Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, University of Texas at Austin
    Present address: Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, USA)

  • Yi Zhong

    (University of Texas MD Anderson Cancer Center)

  • Yue Lu

    (University of Texas MD Anderson Cancer Center)

  • Kiera Rycaj

    (University of Texas MD Anderson Cancer Center)

  • Shuai Gong

    (University of Texas MD Anderson Cancer Center)

  • Xin Chen

    (University of Texas MD Anderson Cancer Center)

  • Xin Liu

    (University of Texas MD Anderson Cancer Center)

  • Hsueh-Ping Chao

    (University of Texas MD Anderson Cancer Center)

  • Pamela Whitney

    (University of Texas MD Anderson Cancer Center)

  • Tammy Calhoun-Davis

    (University of Texas MD Anderson Cancer Center)

  • Yoko Takata

    (University of Texas MD Anderson Cancer Center)

  • Jianjun Shen

    (University of Texas MD Anderson Cancer Center)

  • Vishwanath R. Iyer

    (Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, University of Texas at Austin)

  • Dean G. Tang

    (University of Texas MD Anderson Cancer Center
    Cancer Stem Cell Institute, Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine
    Centers for Cancer Epigenetics, Stem Cell and Developmental Biology, RNA Interference and Non-Coding RNAs and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center)

Abstract

The prostate gland mainly contains basal and luminal cells constructed as a pseudostratified epithelium. Annotation of prostate epithelial transcriptomes provides a foundation for discoveries that can impact disease understanding and treatment. Here we describe a genome-wide transcriptome analysis of human benign prostatic basal and luminal epithelial populations using deep RNA sequencing. Through molecular and biological characterizations, we show that the differential gene-expression profiles account for their distinct functional properties. Strikingly, basal cells preferentially express gene categories associated with stem cells, neurogenesis and ribosomal RNA (rRNA) biogenesis. Consistent with this profile, basal cells functionally exhibit intrinsic stem-like and neurogenic properties with enhanced rRNA transcription activity. Of clinical relevance, the basal cell gene-expression profile is enriched in advanced, anaplastic, castration-resistant and metastatic prostate cancers. Therefore, we link the cell-type-specific gene signatures to aggressive subtypes of prostate cancer and identify gene signatures associated with adverse clinical features.

Suggested Citation

  • Dingxiao Zhang & Daechan Park & Yi Zhong & Yue Lu & Kiera Rycaj & Shuai Gong & Xin Chen & Xin Liu & Hsueh-Ping Chao & Pamela Whitney & Tammy Calhoun-Davis & Yoko Takata & Jianjun Shen & Vishwanath R. , 2016. "Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer," Nature Communications, Nature, vol. 7(1), pages 1-15, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10798
    DOI: 10.1038/ncomms10798
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    Cited by:

    1. Alex Hiroto & Won Kyung Kim & Ariana Pineda & Yongfeng He & Dong-Hoon Lee & Vien Le & Adam W. Olson & Joseph Aldahl & Christian H. Nenninger & Alyssa J. Buckley & Guang-Qian Xiao & Joseph Geradts & Zi, 2022. "Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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