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Calcium imaging of sleep–wake related neuronal activity in the dorsal pons

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  • Julia Cox

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, 230 Li Ka Shing Center, Berkeley, California 94720, USA
    Present address: Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA.)

  • Lucas Pinto

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, 230 Li Ka Shing Center, Berkeley, California 94720, USA
    Present address: Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA.)

  • Yang Dan

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, 230 Li Ka Shing Center, Berkeley, California 94720, USA)

Abstract

The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max). Furthermore, the activity of glutamatergic neurons exhibits a medio-lateral spatial gradient, with medially located neurons more selectively active during REM sleep.

Suggested Citation

  • Julia Cox & Lucas Pinto & Yang Dan, 2016. "Calcium imaging of sleep–wake related neuronal activity in the dorsal pons," Nature Communications, Nature, vol. 7(1), pages 1-7, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10763
    DOI: 10.1038/ncomms10763
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    Cited by:

    1. Kushal Kolar & Daniel Dondorp & Jordi Cornelis Zwiggelaar & Jørgen Høyer & Marios Chatzigeorgiou, 2021. "Mesmerize is a dynamically adaptable user-friendly analysis platform for 2D and 3D calcium imaging data," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Ya-Nan Zhao & Jian-Bo Jiang & Shi-Yuan Tao & Yang Zhang & Ze-Ka Chen & Wei-Min Qu & Zhi-Li Huang & Su-Rong Yang, 2022. "GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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