IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms10702.html
   My bibliography  Save this article

Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

Author

Listed:
  • Janet Berrios

    (Curriculum in Neurobiology, University of North Carolina
    University of North Carolina
    Neuroscience Center, University of North Carolina)

  • Alice M. Stamatakis

    (Curriculum in Neurobiology, University of North Carolina
    Neuroscience Center, University of North Carolina
    University of North Carolina
    Inscopix Inc)

  • Pranish A. Kantak

    (Neuroscience Center, University of North Carolina
    University of North Carolina)

  • Zoe A. McElligott

    (University of North Carolina
    Bowles Center for Alcohol Studies, University of North Carolina)

  • Matthew C. Judson

    (University of North Carolina
    Neuroscience Center, University of North Carolina)

  • Megumi Aita

    (University of North Carolina
    Neuroscience Center, University of North Carolina)

  • Marie Rougie

    (University of North Carolina
    Neuroscience Center, University of North Carolina)

  • Garret D. Stuber

    (Curriculum in Neurobiology, University of North Carolina
    Neuroscience Center, University of North Carolina
    University of North Carolina)

  • Benjamin D. Philpot

    (Curriculum in Neurobiology, University of North Carolina
    University of North Carolina
    Neuroscience Center, University of North Carolina
    Carolina Institute for Developmental Disabilities, University of North Carolina)

Abstract

Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are currently being investigated. Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.

Suggested Citation

  • Janet Berrios & Alice M. Stamatakis & Pranish A. Kantak & Zoe A. McElligott & Matthew C. Judson & Megumi Aita & Marie Rougie & Garret D. Stuber & Benjamin D. Philpot, 2016. "Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation," Nature Communications, Nature, vol. 7(1), pages 1-8, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10702
    DOI: 10.1038/ncomms10702
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms10702
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms10702?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10702. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.