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Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila

Author

Listed:
  • Vladimiros Thoma

    (Graduate School of Life Sciences, Tohoku University
    Max-Planck Institut für Neurobiologie)

  • Stephan Knapek

    (Max-Planck Institut für Neurobiologie)

  • Shogo Arai

    (Graduate School of Information Sciences, Tohoku University)

  • Marion Hartl

    (Max-Planck Institut für Neurobiologie
    Present address: Gut Signalling and Metabolism Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK.)

  • Hiroshi Kohsaka

    (Graduate School of Frontier Sciences, The University of Tokyo)

  • Pudith Sirigrivatanawong

    (Graduate School of Information Sciences, Tohoku University)

  • Ayako Abe

    (Graduate School of Life Sciences, Tohoku University)

  • Koichi Hashimoto

    (Graduate School of Information Sciences, Tohoku University)

  • Hiromu Tanimoto

    (Graduate School of Life Sciences, Tohoku University
    Max-Planck Institut für Neurobiologie)

Abstract

Finding food sources is essential for survival. Insects detect nutrients with external taste receptor neurons. Drosophila possesses multiple taste organs that are distributed throughout its body. However, the role of different taste organs in feeding remains poorly understood. By blocking subsets of sweet taste receptor neurons, we show that receptor neurons in the legs are required for immediate sugar choice. Furthermore, we identify two anatomically distinct classes of sweet taste receptor neurons in the leg. The axonal projections of one class terminate in the thoracic ganglia, whereas the other projects directly to the brain. These two classes are functionally distinct: the brain-projecting neurons are involved in feeding initiation, whereas the thoracic ganglia-projecting neurons play a role in sugar-dependent suppression of locomotion. Distinct receptor neurons for the same taste quality may coordinate early appetitive responses, taking advantage of the legs as the first appendages to contact food.

Suggested Citation

  • Vladimiros Thoma & Stephan Knapek & Shogo Arai & Marion Hartl & Hiroshi Kohsaka & Pudith Sirigrivatanawong & Ayako Abe & Koichi Hashimoto & Hiromu Tanimoto, 2016. "Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila," Nature Communications, Nature, vol. 7(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10678
    DOI: 10.1038/ncomms10678
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    Cited by:

    1. Stanislav Ott & Sangyu Xu & Nicole Lee & Ivan Hong & Jonathan Anns & Danesha Devini Suresh & Zhiyi Zhang & Xianyuan Zhang & Raihanah Harion & Weiying Ye & Vaishnavi Chandramouli & Suresh Jesuthasan & , 2024. "Kalium channelrhodopsins effectively inhibit neurons," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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