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Liver-derived ketone bodies are necessary for food anticipation

Author

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  • Rohit Chavan

    (Unit of Biochemistry, University of Fribourg)

  • Céline Feillet

    (Unit of Biochemistry, University of Fribourg
    Present address: Institut de Biologie Valrose, Circadian Systems Biology UMR7277 CNRS/INSERM/Université de Nice Sophia Antipolis, 06108 Nice, France)

  • Sara S. Fonseca Costa

    (Unit of Biochemistry, University of Fribourg)

  • James E. Delorme

    (Unit of Biochemistry, University of Fribourg
    Present address: Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan 48109, USA)

  • Takashi Okabe

    (Unit of Biochemistry, University of Fribourg)

  • Jürgen A. Ripperger

    (Unit of Biochemistry, University of Fribourg)

  • Urs Albrecht

    (Unit of Biochemistry, University of Fribourg)

Abstract

The circadian system has endowed animals with the ability to anticipate recurring food availability at particular times of day. As daily food anticipation (FA) is independent of the suprachiasmatic nuclei, the central pacemaker of the circadian system, questions arise of where FA signals originate and what role components of the circadian clock might play. Here we show that liver-specific deletion of Per2 in mice abolishes FA, an effect that is rescued by viral overexpression of Per2 in the liver. RNA sequencing indicates that Per2 regulates β-hydroxybutyrate (βOHB) production to induce FA leading to the conclusion that liver Per2 is important for this process. Unexpectedly, we show that FA originates in the liver and not in the brain. However, manifestation of FA involves processing of the liver-derived βOHB signal in the brain, indicating that the food-entrainable oscillator is not located in a single tissue but is of systemic nature.

Suggested Citation

  • Rohit Chavan & Céline Feillet & Sara S. Fonseca Costa & James E. Delorme & Takashi Okabe & Jürgen A. Ripperger & Urs Albrecht, 2016. "Liver-derived ketone bodies are necessary for food anticipation," Nature Communications, Nature, vol. 7(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10580
    DOI: 10.1038/ncomms10580
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