IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms10577.html
   My bibliography  Save this article

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

Author

Listed:
  • Bonnie R. Joubert

    (National Institute of Environmental Health Sciences, National Institutes of Health)

  • Herman T. den Dekker

    (The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam)

  • Janine F. Felix

    (The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam)

  • Jon Bohlin

    (Norwegian Institute of Public Health)

  • Symen Ligthart

    (Erasmus MC, University Medical Center Rotterdam)

  • Emma Beckett

    (School of Environmental and Life Sciences, University of Newcastle
    Food and Nutrition Flagship, CSIRO)

  • Henning Tiemeier

    (Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam)

  • Joyce B. van Meurs

    (Erasmus MC, University Medical Center Rotterdam)

  • Andre G. Uitterlinden

    (Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam)

  • Albert Hofman

    (Erasmus MC, University Medical Center Rotterdam)

  • Siri E. Håberg

    (Norwegian Institute of Public Health)

  • Sarah E. Reese

    (National Institute of Environmental Health Sciences, National Institutes of Health)

  • Marjolein J. Peters

    (Erasmus MC, University Medical Center Rotterdam)

  • Bettina Kulle Andreassen

    (Institute of Clinical Medicine, University of Oslo)

  • Eric A. P. Steegers

    (Erasmus MC, University Medical Center Rotterdam)

  • Roy M. Nilsen

    (Centre for Clinical Research, Haukeland University Hospital)

  • Stein E. Vollset

    (Norwegian Institute of Public Health
    University of Bergen)

  • Øivind Midttun

    (Bevital A/S, Laboratoriebygget)

  • Per M. Ueland

    (University of Bergen
    Laboratory of Clinical Biochemistry, Haukeland University Hospital)

  • Oscar H. Franco

    (Erasmus MC, University Medical Center Rotterdam)

  • Abbas Dehghan

    (Erasmus MC, University Medical Center Rotterdam)

  • Johan C. de Jongste

    (Erasmus MC, University Medical Center Rotterdam)

  • Michael C. Wu

    (Public Health Sciences Program, Fred Hutchinson Cancer Research Center)

  • Tianyuan Wang

    (National Institute of Environmental Health Sciences, National Institutes of Health)

  • Shyamal D. Peddada

    (National Institute of Environmental Health Sciences, National Institutes of Health)

  • Vincent W. V. Jaddoe

    (The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam)

  • Wenche Nystad

    (Norwegian Institute of Public Health)

  • Liesbeth Duijts

    (The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam)

  • Stephanie J. London

    (National Institute of Environmental Health Sciences, National Institutes of Health)

Abstract

Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development and disease are poorly understood: epigenetics may be involved. We examine the association between maternal plasma folate during pregnancy and epigenome-wide DNA methylation using Illumina’s HumanMethyl450 Beadchip in 1,988 newborns from two European cohorts. Here we report the combined covariate-adjusted results using meta-analysis and employ pathway and gene expression analyses. Four-hundred forty-three CpGs (320 genes) are significantly associated with maternal plasma folate levels during pregnancy (false discovery rate 5%); 48 are significant after Bonferroni correction. Most genes are not known for folate biology, including APC2, GRM8, SLC16A12, OPCML, PRPH, LHX1, KLK4 and PRSS21. Some relate to birth defects other than neural tube defects, neurological functions or varied aspects of embryonic development. These findings may inform how maternal folate impacts the developing epigenome and health outcomes in offspring.

Suggested Citation

  • Bonnie R. Joubert & Herman T. den Dekker & Janine F. Felix & Jon Bohlin & Symen Ligthart & Emma Beckett & Henning Tiemeier & Joyce B. van Meurs & Andre G. Uitterlinden & Albert Hofman & Siri E. Håberg, 2016. "Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns," Nature Communications, Nature, vol. 7(1), pages 1-8, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10577
    DOI: 10.1038/ncomms10577
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms10577
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms10577?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Eric M. Nickels & Shaobo Li & Swe Swe Myint & Katti Arroyo & Qianxi Feng & Kimberly D. Siegmund & Adam J. de Smith & Joseph L. Wiemels, 2022. "DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Prachand Issarapu & Manisha Arumalla & Hannah R. Elliott & Suraj S. Nongmaithem & Alagu Sankareswaran & Modupeh Betts & Sara Sajjadi & Noah J. Kessler & Swati Bayyana & Sohail R. Mansuri & Maria Derak, 2023. "DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10577. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.