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Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

Author

Listed:
  • Ake T. Lu

    (David Geffen School of Medicine, University of California Los Angeles)

  • Eilis Hannon

    (University of Exeter Medical School, University of Exeter)

  • Morgan E. Levine

    (David Geffen School of Medicine, University of California Los Angeles)

  • Ke Hao

    (The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai)

  • Eileen M. Crimmins

    (Davis School of Gerontology, University of Southern California, Ethel Percy Andrus Gerontology Center)

  • Katie Lunnon

    (University of Exeter Medical School, University of Exeter)

  • Alexey Kozlenkov

    (Icahn School of Medicine at Mount Sinai
    James J. Peters VA Medical Center)

  • Jonathan Mill

    (University of Exeter Medical School, University of Exeter
    Institute of Psychiatry, King’s College London)

  • Stella Dracheva

    (Icahn School of Medicine at Mount Sinai
    James J. Peters VA Medical Center)

  • Steve Horvath

    (David Geffen School of Medicine, University of California Los Angeles
    Biostatistics, School of Public Health, University of California Los Angeles)

Abstract

DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the ‘epigenetic clock’. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant (P

Suggested Citation

  • Ake T. Lu & Eilis Hannon & Morgan E. Levine & Ke Hao & Eileen M. Crimmins & Katie Lunnon & Alexey Kozlenkov & Jonathan Mill & Stella Dracheva & Steve Horvath, 2016. "Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum," Nature Communications, Nature, vol. 7(1), pages 1-9, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10561
    DOI: 10.1038/ncomms10561
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