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Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration

Author

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  • Takamitsu Maruyama

    (Center for Oral Biology, University of Rochester Medical Center
    Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center)

  • Jaeim Jeong

    (Center for Oral Biology, University of Rochester Medical Center)

  • Tzong-Jen Sheu

    (Center for Musculoskeletal Research, University of Rochester Medical Center)

  • Wei Hsu

    (Center for Oral Biology, University of Rochester Medical Center
    Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center
    Wilmot Cancer Institute, University of Rochester Medical Center)

Abstract

The suture mesenchyme serves as a growth centre for calvarial morphogenesis and has been postulated to act as the niche for skeletal stem cells. Aberrant gene regulation causes suture dysmorphogenesis resulting in craniosynostosis, one of the most common craniofacial deformities. Owing to various limitations, especially the lack of suture stem cell isolation, reconstruction of large craniofacial bone defects remains highly challenging. Here we provide the first evidence for an Axin2-expressing stem cell population with long-term self-renewing, clonal expanding and differentiating abilities during calvarial development and homeostastic maintenance. These cells, which reside in the suture midline, contribute directly to injury repair and skeletal regeneration in a cell autonomous fashion. Our findings demonstrate their true identity as skeletal stem cells with innate capacities to replace the damaged skeleton in cell-based therapy, and permit further elucidation of the stem cell-mediated craniofacial skeletogenesis, leading to revealing the complex nature of congenital disease and regenerative medicine.

Suggested Citation

  • Takamitsu Maruyama & Jaeim Jeong & Tzong-Jen Sheu & Wei Hsu, 2016. "Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration," Nature Communications, Nature, vol. 7(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10526
    DOI: 10.1038/ncomms10526
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    Cited by:

    1. Alexandra N. Rindone & Xiaonan Liu & Stephanie Farhat & Alexander Perdomo-Pantoja & Timothy F. Witham & Daniel L. Coutu & Mei Wan & Warren L. Grayson, 2021. "Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. D’Juan T. Farmer & Jennifer E. Dukov & Hung-Jhen Chen & Claire Arata & Jose Hernandez-Trejo & Pengfei Xu & Camilla S. Teng & Robert E. Maxson & J. Gage Crump, 2024. "Cellular transitions during cranial suture establishment in zebrafish," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Greg Holmes & Ana S. Gonzalez-Reiche & Madrikha Saturne & Susan M. Motch Perrine & Xianxiao Zhou & Ana C. Borges & Bhavana Shewale & Joan T. Richtsmeier & Bin Zhang & Harm Bakel & Ethylin Wang Jabs, 2021. "Single-cell analysis identifies a key role for Hhip in murine coronal suture development," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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