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The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells

Author

Listed:
  • Rouven Ding

    (Institute of Genetics, Johannes Gutenberg University)

  • Kevin Weynans

    (Institute of Genetics, Johannes Gutenberg University
    Present address: Institute of Reconstructive Neurobiology, University Bonn, 53127 Bonn, Germany.)

  • Torsten Bossing

    (School of Biomedical and Healthcare Sciences, Plymouth University)

  • Claudia S. Barros

    (Peninsula School of Medicine, Plymouth University)

  • Christian Berger

    (Institute of Genetics, Johannes Gutenberg University)

Abstract

Stem cells control their mitotic activity to decide whether to proliferate or to stay in quiescence. Drosophila neural stem cells (NSCs) are quiescent at early larval stages, when they are reactivated in response to metabolic changes. Here we report that cell-contact inhibition of growth through the canonical Hippo signalling pathway maintains NSC quiescence. Loss of the core kinases hippo or warts leads to premature nuclear localization of the transcriptional co-activator Yorkie and initiation of growth and proliferation in NSCs. Yorkie is necessary and sufficient for NSC reactivation, growth and proliferation. The Hippo pathway activity is modulated via inter-cellular transmembrane proteins Crumbs and Echinoid that are both expressed in a nutrient-dependent way in niche glial cells and NSCs. Loss of crumbs or echinoid in the niche only is sufficient to reactivate NSCs. Finally, we provide evidence that the Hippo pathway activity discriminates quiescent from non-quiescent NSCs in the Drosophila nervous system.

Suggested Citation

  • Rouven Ding & Kevin Weynans & Torsten Bossing & Claudia S. Barros & Christian Berger, 2016. "The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells," Nature Communications, Nature, vol. 7(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10510
    DOI: 10.1038/ncomms10510
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    Cited by:

    1. Yang Gao & Ye Sing Tan & Jiaen Lin & Liang Yuh Chew & Htet Yamin Aung & Brinda Palliyana & Mahekta R. Gujar & Kun-Yang Lin & Shu Kondo & Hongyan Wang, 2024. "SUMOylation of Warts kinase promotes neural stem cell reactivation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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