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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Author

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  • Yingchang Lu

    (The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai
    The Icahn School of Medicine at Mount Sinai)

  • Felix R. Day

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Stefan Gustafsson

    (Science for Life Laboratory, Uppsala University
    Molecular Epidemiology, Uppsala University)

  • Martin L. Buchkovich

    (University of North Carolina)

  • Jianbo Na

    (The Icahn School of Medicine at Mount Sinai)

  • Veronique Bataille

    (West Herts NHS Trust
    King's College London)

  • Diana L. Cousminer

    (Institute for Molecular Medicine Finland, University of Helsinki)

  • Zari Dastani

    (Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University)

  • Alexander W. Drong

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford)

  • Tõnu Esko

    (Estonian Genome Center, Univeristy of Tartu
    Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Boston Children's Hospital
    Harvard Medical School)

  • David M. Evans

    (University of Queensland Diamantina Institute, Translational Research Institute
    MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol)

  • Mario Falchi

    (King's College London
    School of Public Health, Imperial College London)

  • Mary F. Feitosa

    (Washington University School of Medicine)

  • Teresa Ferreira

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford)

  • Åsa K. Hedman

    (Science for Life Laboratory, Uppsala University
    Molecular Epidemiology, Uppsala University
    Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford)

  • Robin Haring

    (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
    European University of Applied Sciences, Faculty of Applied Public Health)

  • Pirro G. Hysi

    (King's College London)

  • Mark M. Iles

    (Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds)

  • Anne E. Justice

    (University of North Carolina at Chapel Hill)

  • Stavroula Kanoni

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    Wellcome Trust Sanger Institute, Human Genetics)

  • Vasiliki Lagou

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital)

  • Rui Li

    (Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University)

  • Xin Li

    (Harvard School of Public Health)

  • Adam Locke

    (Center for Statistical Genetics, University of Michigan)

  • Chen Lu

    (Boston University School of Public Health)

  • Reedik Mägi

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford
    Estonian Genome Center, Univeristy of Tartu)

  • John R. B. Perry

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Tune H. Pers

    (Boston Children's Hospital
    Harvard Medical School
    Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    Medical and Population Genetics Program, Broad Institute of MIT and Harvard)

  • Qibin Qi

    (Albert Einstein College of Medicine)

  • Marianna Sanna

    (King's College London
    School of Public Health, Imperial College London)

  • Ellen M. Schmidt

    (University of Michigan)

  • William R. Scott

    (Imperial College London
    Ealing Hospital NHS Trust)

  • Dmitry Shungin

    (Lund University Diabetes Centre, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial
    Unit of Medicine, Umeå University
    Umeå University)

  • Alexander Teumer

    (Institute for Community Medicine, University Medicine Greifswald
    Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald)

  • Anna A. E. Vinkhuyzen

    (Queensland Brain Institute, The University of Queensland)

  • Ryan W. Walker

    (The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai
    The Icahn School of Medicine at Mount Sinai)

  • Harm-Jan Westra

    (Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology
    Brigham and Women’s Hospital and Harvard Medical School
    Partners Center for Personalized Genetic Medicine)

  • Mingfeng Zhang

    (Brigham and Women's Hospital)

  • Weihua Zhang

    (Imperial College London
    Ealing Hospital NHS Trust)

  • Jing Hua Zhao

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Zhihong Zhu

    (Queensland Brain Institute, The University of Queensland)

  • Uzma Afzal

    (Imperial College London
    Ealing Hospital NHS Trust)

  • Tarunveer Singh Ahluwalia

    (Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sceinces, University of Copenhagen
    Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region
    Steno Diabetes Center A/S)

  • Stephan J. L. Bakker

    (University of Groningen, University Medical Center Groningen)

  • Claire Bellis

    (Texas Biomedical Research Institute)

  • Amélie Bonnefond

    (CNRS UMR 8199
    European Genomic Institute for Diabetes
    Université de Lille 2)

  • Katja Borodulin

    (National Institute for Health and Welfare)

  • Aron S. Buchman

    (Rush Alzheimer's Disease Center, Rush University Medical Center)

  • Tommy Cederholm

    (Clinical Nutrition and Metabolism, Uppsala University)

  • Audrey C. Choh

    (Lifespan Health Research Center, Wright State University Boonshoft School of Medicine)

  • Hyung Jin Choi

    (Seoul National University College of Medicine)

  • Joanne E. Curran

    (South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley)

  • Lisette C. P. G. M. de Groot

    (Wageningen University)

  • Philip L. De Jager

    (Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology
    Harvard Medical School
    Program in Translational NeuroPsychiatric Genomics, Brigham and Women’s Hospital)

  • Rosalie A. M. Dhonukshe-Rutten

    (Wageningen University)

  • Anke W. Enneman

    (Erasmus Medical Center)

  • Elodie Eury

    (CNRS UMR 8199
    European Genomic Institute for Diabetes
    Université de Lille 2)

  • Daniel S. Evans

    (California Pacific Medical Center Research Institute)

  • Tom Forsen

    (University of Helsinki)

  • Nele Friedrich

    (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald)

  • Frédéric Fumeron

    (INSERM, UMR_S 1138, Centre de Recherche des Cordeliers
    Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers
    Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers
    Univ Paris Diderot, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers)

  • Melissa E. Garcia

    (Laboratory of Epidemiology and Population Sciences, National Institute on Aging)

  • Simone Gärtner

    (University Medicine Greifswald)

  • Bok-Ghee Han

    (Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex)

  • Aki S. Havulinna

    (National Institute for Health and Welfare)

  • Caroline Hayward

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Dena Hernandez

    (Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health)

  • Hans Hillege

    (University of Groningen, University Medical Center Groningen)

  • Till Ittermann

    (Institute for Community Medicine, University Medicine Greifswald)

  • Jack W. Kent

    (Texas Biomedical Research Institute)

  • Ivana Kolcic

    (Faculty of Medicine, University of Split)

  • Tiina Laatikainen

    (National Institute for Health and Welfare
    Hospital District of North Karelia
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland)

  • Jari Lahti

    (Folkhälsan Research Centre
    Institute of Behavioural Sciences, University of Helsinki)

  • Irene Mateo Leach

    (University of Groningen, University Medical Center Groningen)

  • Christine G. Lee

    (Oregon Health and Science University
    Research Service, Veterans Affairs Medical Center)

  • Jong-Young Lee

    (Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex)

  • Tian Liu

    (Max Planck Institute for Molecular Genetics
    Max Planck Institute for Human Development)

  • Youfang Liu

    (Thurston Arthritis Research Center, University of North Carolina at Chapel Hill)

  • Stéphane Lobbens

    (CNRS UMR 8199
    European Genomic Institute for Diabetes
    Université de Lille 2)

  • Marie Loh

    (Imperial College London
    Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR))

  • Leo-Pekka Lyytikäinen

    (University of Tampere School of Medicine
    Fimlab Laboratories and School of Medicine, University of Tampere)

  • Carolina Medina-Gomez

    (Erasmus Medical Center
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Erasmus Medical Center)

  • Karl Michaëlsson

    (Orthopedics, Uppsala University)

  • Mike A. Nalls

    (Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health)

  • Carrie M. Nielson

    (School of Public Health, Oregon Health & Science University
    Bone & Mineral Unit, Oregon Health & Science University)

  • Laticia Oozageer

    (Ealing Hospital NHS Trust)

  • Laura Pascoe

    (Institute of Cell & Molecular Biosciences, Newcastle University)

  • Lavinia Paternoster

    (MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol)

  • Ozren Polašek

    (Faculty of Medicine, University of Split
    Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place)

  • Samuli Ripatti

    (Institute for Molecular Medicine Finland, University of Helsinki
    Wellcome Trust Sanger Institute, Human Genetics
    Hjelt Institute, University of Helsinki)

  • Mark A. Sarzynski

    (Human Genomics Laboratory, Pennington Biomedical Research Center)

  • Chan Soo Shin

    (Seoul National University College of Medicine)

  • Nina Smolej Narančić

    (Institute for Anthropological Research)

  • Dominik Spira

    (The Berlin Aging Study II; Research Group on Geriatrics; Charité—Universitätsmedizin Berlin
    Research Group on Geriatrics
    Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin)

  • Priya Srikanth

    (School of Public Health, Oregon Health & Science University
    Bone & Mineral Unit, Oregon Health & Science University)

  • Elisabeth Steinhagen-Thiessen

    (The Berlin Aging Study II; Research Group on Geriatrics; Charité—Universitätsmedizin Berlin
    Research Group on Geriatrics
    Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin)

  • Yun Ju Sung

    (Washington University School of Medicine)

  • Karin M. A. Swart

    (EMGO Institute for Health and Care Research, VU University Medical Center
    VUMC)

  • Leena Taittonen

    (University of Oulu
    Vaasa Central Hospital)

  • Toshiko Tanaka

    (Translational Gerontology Branch, National Institute on Aging)

  • Emmi Tikkanen

    (Institute for Molecular Medicine Finland, University of Helsinki
    Hjelt Institute, University of Helsinki)

  • Nathalie van der Velde

    (Erasmus Medical Center)

  • Natasja M. van Schoor

    (EMGO Institute for Health and Care Research, VU University Medical Center
    VUMC)

  • Niek Verweij

    (University of Groningen, University Medical Center Groningen)

  • Alan F. Wright

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Lei Yu

    (Rush Alzheimer's Disease Center, Rush University Medical Center)

  • Joseph M. Zmuda

    (Department of Epidemiology; University of Pittsburgh
    University of Pittsburgh)

  • Niina Eklund

    (National Institute for Health and Welfare)

  • Terrence Forrester

    (Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies)

  • Niels Grarup

    (Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Anne U. Jackson

    (Center for Statistical Genetics, University of Michigan)

  • Kati Kristiansson

    (Institute for Molecular Medicine Finland, University of Helsinki
    National Institute for Health and Welfare)

  • Teemu Kuulasmaa

    (Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland)

  • Johanna Kuusisto

    (Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
    University of Eastern Finland
    Kuopio University Hospital)

  • Peter Lichtner

    (Institute of Human Genetics, Helmholtz Zentrum München—German Research Center for Environmental Health)

  • Jian'an Luan

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Anubha Mahajan

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford)

  • Satu Männistö

    (National Institute for Health and Welfare)

  • Cameron D. Palmer

    (Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Boston Children's Hospital)

  • Janina S. Ried

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health)

  • Robert A. Scott

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Alena Stancáková

    (University of Eastern Finland and Kuopio University Hospital)

  • Peter J. Wagner

    (Institute for Molecular Medicine Finland, University of Helsinki
    National Institute for Health and Welfare)

  • Ayse Demirkan

    (Genetic Epidemiology Unit, Erasmus University Medical Center)

  • Angela Döring

    (Institute of Epidemiology I, Helmholtz Zentrum München—German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health)

  • Vilmundur Gudnason

    (Icelandic Heart Association
    University of Iceland, Faculty of Medicine)

  • Douglas P. Kiel

    (Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School
    Institute for Aging Research Hebrew Senior Life)

  • Brigitte Kühnel

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health)

  • Massimo Mangino

    (King's College London)

  • Barbara Mcknight

    (Cardiovascular Health Research Unit, University of Washington
    Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center
    University of Washington)

  • Cristina Menni

    (King's College London)

  • Jeffrey R. O'Connell

    (Program for Personalized and Genomic Medicine, Diabetes and Nutrition, University of Maryland School of Medicine)

  • Ben A. Oostra

    (Genetic Epidemiology Unit, Erasmus University Medical Center)

  • Alan R. Shuldiner

    (Program for Personalized and Genomic Medicine, Diabetes and Nutrition, University of Maryland School of Medicine
    Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center)

  • Kijoung Song

    (Genetics, Projects Clinical Platforms and Sciences, GlaxoSmithKline)

  • Liesbeth Vandenput

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg)

  • Cornelia M. van Duijn

    (Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Genetic Epidemiology Unit, Erasmus University Medical Center
    Center for Medical Systems Biology)

  • Peter Vollenweider

    (University Hospital Lausanne (CHUV) and University of Lausanne)

  • Charles C. White

    (Boston University School of Public Health)

  • Michael Boehnke

    (Center for Statistical Genetics, University of Michigan)

  • Yvonne Boettcher

    (University of Leipzig, IFB Adiposity Diseases
    University of Leipzig)

  • Richard S. Cooper

    (Stritch School of Medicine, Loyola University Chicago)

  • Nita G. Forouhi

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • Christian Gieger

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health)

  • Harald Grallert

    (Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
    German Center for Diabetes Research (DZD))

  • Aroon Hingorani

    (Institute of Cardiovascular Science, University College London)

  • Torben Jørgensen

    (Faculty of Health and Medical Sciences, University of Copenhagen
    Faculty of Medicine, University of Aalborg
    Research Centre for Prevention and Health)

  • Pekka Jousilahti

    (National Institute for Health and Welfare)

  • Mika Kivimaki

    (UCL)

  • Meena Kumari

    (UCL)

  • Markku Laakso

    (Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
    University of Eastern Finland
    Kuopio University Hospital)

  • Claudia Langenberg

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
    UCL)

  • Allan Linneberg

    (Research Centre for Prevention and Health, Glostrup Hospital)

  • Amy Luke

    (Stritch School of Medicine, Loyola University Chicago)

  • Colin A. Mckenzie

    (Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies)

  • Aarno Palotie

    (Institute for Molecular Medicine Finland, University of Helsinki
    Wellcome Trust Sanger Institute, Human Genetics
    Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit)

  • Oluf Pedersen

    (Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Annette Peters

    (Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health)

  • Konstantin Strauch

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
    Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität)

  • Bamidele O. Tayo

    (Stritch School of Medicine, Loyola University Chicago)

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus)

  • David A. Bennett

    (Rush Alzheimer's Disease Center, Rush University Medical Center)

  • Lars Bertram

    (School of Public Health, Faculty of Medicine, Imperial College London
    Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck)

  • John Blangero

    (South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley)

  • Matthias Blüher

    (University of Leipzig, IFB Adiposity Diseases
    University of Leipzig)

  • Claude Bouchard

    (Human Genomics Laboratory, Pennington Biomedical Research Center)

  • Harry Campbell

    (Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place)

  • Nam H. Cho

    (Ajou University School of Medicine)

  • Steven R. Cummings

    (California Pacific Medical Center Research Institute)

  • Stefan A. Czerwinski

    (Lifespan Health Research Center, Wright State University Boonshoft School of Medicine)

  • Ilja Demuth

    (The Berlin Aging Study II; Research Group on Geriatrics; Charité—Universitätsmedizin Berlin
    Research Group on Geriatrics
    Institute of Medical and Human Genetics, Charité—Universitätsmedizin Berlin)

  • Rahel Eckardt

    (The Berlin Aging Study II; Research Group on Geriatrics; Charité—Universitätsmedizin Berlin
    Research Group on Geriatrics)

  • Johan G. Eriksson

    (National Institute for Health and Welfare
    University of Helsinki
    Folkhälsan Research Centre)

  • Luigi Ferrucci

    (Translational Gerontology Branch, National Institute on Aging)

  • Oscar H. Franco

    (Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Erasmus Medical Center)

  • Philippe Froguel

    (CNRS UMR 8199
    European Genomic Institute for Diabetes
    Université de Lille 2)

  • Ron T. Gansevoort

    (University of Groningen, University Medical Center Groningen)

  • Torben Hansen

    (Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    Faculty of Health Sciences, University of Southern Denmark)

  • Tamara B. Harris

    (Laboratory of Epidemiology and Population Sciences, National Institute on Aging)

  • Nicholas Hastie

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Markku Heliövaara

    (National Institute for Health and Welfare)

  • Albert Hofman

    (Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Erasmus Medical Center)

  • Joanne M. Jordan

    (Thurston Arthritis Research Center, University of North Carolina at Chapel Hill)

  • Antti Jula

    (National Institute for Health and Welfare)

  • Mika Kähönen

    (Tampere University Hospital
    University of Tampere School of Medicine)

  • Eero Kajantie

    (National Institute for Health and Welfare
    Children's Hospital, Helsinki University Hospital and University of Helsinki
    MRC Oulu, Oulu University Hospital and University of Oulu)

  • Paul B. Knekt

    (National Institute for Health and Welfare)

  • Seppo Koskinen

    (National Institute for Health and Welfare)

  • Peter Kovacs

    (University of Leipzig, IFB Adiposity Diseases)

  • Terho Lehtimäki

    (University of Tampere School of Medicine
    Fimlab Laboratories and School of Medicine, University of Tampere)

  • Lars Lind

    (Uppsala University)

  • Yongmei Liu

    (Center for Human Genetics, Wake Forest School of Medicine)

  • Eric S. Orwoll

    (Bone & Mineral Unit, Oregon Health & Science University)

  • Clive Osmond

    (MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital)

  • Markus Perola

    (Institute for Molecular Medicine Finland, University of Helsinki
    Estonian Genome Center, Univeristy of Tartu
    National Institute for Health and Welfare)

  • Louis Pérusse

    (Laval University
    Institute of Nutrition and Functional Foods, Laval University)

  • Olli T. Raitakari

    (Turku University Hospital
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku)

  • Tuomo Rankinen

    (Human Genomics Laboratory, Pennington Biomedical Research Center)

  • D. C. Rao

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

  • Treva K. Rice

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Fernando Rivadeneira

    (Erasmus Medical Center
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Erasmus Medical Center)

  • Igor Rudan

    (Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place)

  • Veikko Salomaa

    (National Institute for Health and Welfare)

  • Thorkild I. A. Sørensen

    (MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol
    Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region)

  • Michael Stumvoll

    (University of Leipzig, IFB Adiposity Diseases
    University of Leipzig)

  • Anke Tönjes

    (University of Leipzig)

  • Bradford Towne

    (Lifespan Health Research Center, Wright State University Boonshoft School of Medicine)

  • Gregory J. Tranah

    (California Pacific Medical Center Research Institute)

  • Angelo Tremblay

    (Laval University)

  • André G. Uitterlinden

    (Erasmus Medical Center
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Erasmus Medical Center)

  • Pim van der Harst

    (University of Groningen, University Medical Center Groningen
    Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute
    University Medical Center Groningen, University of Groningen)

  • Erkki Vartiainen

    (National Institute for Health and Welfare)

  • Jorma S. Viikari

    (University of Turku)

  • Veronique Vitart

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Marie-Claude Vohl

    (Institute of Nutrition and Functional Foods, Laval University
    School of Nutrition, Laval University)

  • Henry Völzke

    (Institute for Community Medicine, University Medicine Greifswald
    DZHK (German Centre for Cardiovascular Research), partner site Greifswald
    DZD (German Centre for Diabetes Research), partner site Greifswald)

  • Mark Walker

    (Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology
    Institute of Cellular Medicine, Newcastle University)

  • Henri Wallaschofski

    (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
    DZHK (German Centre for Cardiovascular Research), partner site Greifswald)

  • Sarah Wild

    (Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh)

  • James F. Wilson

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
    Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place)

  • Loïc Yengo

    (CNRS UMR 8199
    European Genomic Institute for Diabetes
    Université de Lille 2)

  • D. Timothy Bishop

    (Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds)

  • Ingrid B. Borecki

    (Washington University School of Medicine
    Analytical Genetics Group, Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc.)

  • John C. Chambers

    (Imperial College London
    Ealing Hospital NHS Trust
    Imperial College Healthcare NHS Trust)

  • L. Adrienne Cupples

    (Boston University School of Public Health
    National Heart, Lung, and Blood Institute, the Framingham Heart Study)

  • Abbas Dehghan

    (Erasmus Medical Center)

  • Panos Deloukas

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    Wellcome Trust Sanger Institute, Human Genetics
    Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University)

  • Ghazaleh Fatemifar

    (MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol)

  • Caroline Fox

    (Harvard Medical School
    National Heart, Lung, and Blood Institute, the Framingham Heart Study)

  • Terrence S. Furey

    (University of North Carolina
    University of North Carolina)

  • Lude Franke

    (University of Groningen, University Medical Center Groningen
    University Medical Center Groningen, University of Groningen)

  • Jiali Han

    (Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center)

  • David J. Hunter

    (Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Harvard School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health)

  • Juha Karjalainen

    (University Medical Center Groningen, University of Groningen)

  • Fredrik Karpe

    (Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
    Oxford NIHR Biomedical Research Centre)

  • Robert C. Kaplan

    (Albert Einstein College of Medicine)

  • Jaspal S. Kooner

    (Ealing Hospital NHS Trust
    Imperial College Healthcare NHS Trust
    National Heart and Lung Institute, Imperial College London)

  • Mark I. McCarthy

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
    Oxford NIHR Biomedical Research Centre)

  • Joanne M. Murabito

    (Boston University School of Medicine, Section of General Internal Medicine
    NHLBI's and Boston University's Framingham Heart Study)

  • Andrew P. Morris

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford
    University of Liverpool)

  • Julia A. N. Bishop

    (Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds)

  • Kari E. North

    (University of North Carolina at Chapel Hill)

  • Claes Ohlsson

    (Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg)

  • Ken K. Ong

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
    MRC Unit for Lifelong Health and Ageing at UCL
    University of Cambridge)

  • Inga Prokopenko

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford
    School of Public Health, Imperial College London
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital)

  • J. Brent Richards

    (Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University
    Lady Davis Institute, Jewish General Hospital, McGill University
    King’s College London
    Lady Davis Institute, Jewish General Hospital, McGill University)

  • Eric E. Schadt

    (Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Tim D. Spector

    (King's College London)

  • Elisabeth Widén

    (Institute for Molecular Medicine Finland, University of Helsinki)

  • Cristen J. Willer

    (University of Michigan
    University of Michigan
    University of Michigan)

  • Jian Yang

    (Queensland Brain Institute, The University of Queensland)

  • Erik Ingelsson

    (Science for Life Laboratory, Uppsala University
    Molecular Epidemiology, Uppsala University
    Stanford University School of Medicine)

  • Karen L. Mohlke

    (University of North Carolina)

  • Joel N. Hirschhorn

    (Broad Institute of the Massachusetts Institute of Technology and Harvard University
    Boston Children's Hospital
    Harvard Medical School)

  • John Andrew Pospisilik

    (Max Planck Institute of Immunobiology and Epigenetics)

  • M. Carola Zillikens

    (Erasmus Medical Center
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Cecilia Lindgren

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford
    Broad Institute of the Massachusetts Institute of Technology and Harvard University
    The Big Data Institute, University of Oxford)

  • Tuomas Oskari Kilpeläinen

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
    Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Ruth J. F. Loos

    (The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai
    The Icahn School of Medicine at Mount Sinai
    MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
    The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai)

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P

Suggested Citation

  • Yingchang Lu & Felix R. Day & Stefan Gustafsson & Martin L. Buchkovich & Jianbo Na & Veronique Bataille & Diana L. Cousminer & Zari Dastani & Alexander W. Drong & Tõnu Esko & David M. Evans & Mario Fa, 2016. "New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk," Nature Communications, Nature, vol. 7(1), pages 1-15, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10495
    DOI: 10.1038/ncomms10495
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    Cited by:

    1. William R. Reay & Dylan J. Kiltschewskij & Maria A. Biase & Zachary F. Gerring & Kousik Kundu & Praveen Surendran & Laura A. Greco & Erin D. Clarke & Clare E. Collins & Alison M. Mondul & Demetrius Al, 2024. "Genetic influences on circulating retinol and its relationship to human health," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Zipeng Liu & Yiming Qin & Tian Wu & Justin D. Tubbs & Larry Baum & Timothy Shin Heng Mak & Miaoxin Li & Yan Dora Zhang & Pak Chung Sham, 2023. "Reciprocal causation mixture model for robust Mendelian randomization analysis using genome-scale summary data," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Zhaotong Lin & Yangqing Deng & Wei Pan, 2021. "Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model," PLOS Genetics, Public Library of Science, vol. 17(11), pages 1-25, November.

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