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Periodic patterning of the Drosophila eye is stabilized by the diffusible activator Scabrous

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  • Avishai Gavish

    (Weizmann Institute of Science
    Sackler Faculty of Medicine, Geha Mental Health Center, Felsenstein Medical Research Center, Rabin Medical Center, Tel Aviv University, Bellinson Campus)

  • Arkadi Shwartz

    (Weizmann Institute of Science)

  • Abraham Weizman

    (Sackler Faculty of Medicine, Geha Mental Health Center, Felsenstein Medical Research Center, Rabin Medical Center, Tel Aviv University, Bellinson Campus)

  • Eyal Schejter

    (Weizmann Institute of Science)

  • Ben-Zion Shilo

    (Weizmann Institute of Science)

  • Naama Barkai

    (Weizmann Institute of Science)

Abstract

Generation of periodic patterns is fundamental to the differentiation of multiple tissues during development. How such patterns form robustly is still unclear. The Drosophila eye comprises ∼750 units, whose crystalline order is set during differentiation of the eye imaginal disc: an activation wave sweeping across the disc is coupled to lateral inhibition, sequentially selecting pro-neural cells. Using mathematical modelling, here we show that this template-based lateral inhibition is highly sensitive to spatial variations in biochemical parameters and cell sizes. We reveal the basis of this sensitivity, and suggest that it can be overcome by assuming a short-range diffusible activator. Clonal experiments identify Scabrous, a previously implicated inhibitor, as the predicted activator. Our results reveal the mechanism by which periodic patterning in the fly eye is stabilized against spatial variations, highlighting how the need to maintain robustness shapes the design of patterning circuits.

Suggested Citation

  • Avishai Gavish & Arkadi Shwartz & Abraham Weizman & Eyal Schejter & Ben-Zion Shilo & Naama Barkai, 2016. "Periodic patterning of the Drosophila eye is stabilized by the diffusible activator Scabrous," Nature Communications, Nature, vol. 7(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10461
    DOI: 10.1038/ncomms10461
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    Cited by:

    1. George Courcoubetis & Sammi Ali & Sergey V Nuzhdin & Paul Marjoram & Stephan Haas, 2019. "Threshold response to stochasticity in morphogenesis," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-25, January.

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