Author
Listed:
- Lee M. Butcher
(UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
Imperial College London)
- Mitsuteru Ito
(University of Cambridge)
- Minodora Brimpari
(Anne McLaren Laboratory, Wellcome Trust and Medical Research Council Stem Cell Institute, University of Cambridge)
- Tiffany J. Morris
(UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
Cambridge Epigenetix)
- Filipa A. C. Soares
(Anne McLaren Laboratory, Wellcome Trust and Medical Research Council Stem Cell Institute, University of Cambridge
Wellcome Trust Sanger Institute)
- Lars Ährlund-Richter
(Karolinska Institutet)
- Nessa Carey
(PraxisUnico, The Jeffreys Building, St John’s Innovation Park)
- Ludovic Vallier
(Anne McLaren Laboratory, Wellcome Trust and Medical Research Council Stem Cell Institute, University of Cambridge
Wellcome Trust Sanger Institute)
- Anne C. Ferguson-Smith
(University of Cambridge)
- Stephan Beck
(UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK)
Abstract
Non-CG methylation is an unexplored epigenetic hallmark of pluripotent stem cells. Here we report that a reduction in non-CG methylation is associated with impaired differentiation capacity into endodermal lineages. Genome-wide analysis of 2,670 non-CG sites in a discovery cohort of 25 phenotyped human induced pluripotent stem cell (hiPSC) lines revealed unidirectional loss (Δβ=13%, P
Suggested Citation
Lee M. Butcher & Mitsuteru Ito & Minodora Brimpari & Tiffany J. Morris & Filipa A. C. Soares & Lars Ährlund-Richter & Nessa Carey & Ludovic Vallier & Anne C. Ferguson-Smith & Stephan Beck, 2016.
"Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells,"
Nature Communications, Nature, vol. 7(1), pages 1-8, April.
Handle:
RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10458
DOI: 10.1038/ncomms10458
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