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Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers

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  • Susana Llanos

    (Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO))

  • Juana M. García-Pedrero

    (Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo)

  • Lucia Morgado-Palacin

    (Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO))

  • Juan P. Rodrigo

    (Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo)

  • Manuel Serrano

    (Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO))

Abstract

The levels, regulation and prognostic value of p21 in head and neck squamous cell carcinomas (HNSCC) has been puzzling for years. Here, we report a new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway. We find that non-phosphorylated 4E-BP1 interacts with p21 and induces its degradation. Accordingly, hyper-activation of mTORC1 results in phosphorylation of 4E-BP1 and stabilization of p21. In HNSCC, p21 levels strongly correlate with mTORC1 activity but not with p53 status. Finally, clinical data indicate that HNSCC patients with p21 and phospho-S6-double-positive tumours present a better disease-specific survival. We conclude that over-activation of the mTORC1/4E-BP1/p21 pathway is a frequent and clinically relevant alteration in HNSCC.

Suggested Citation

  • Susana Llanos & Juana M. García-Pedrero & Lucia Morgado-Palacin & Juan P. Rodrigo & Manuel Serrano, 2016. "Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers," Nature Communications, Nature, vol. 7(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10438
    DOI: 10.1038/ncomms10438
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