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Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children

Author

Listed:
  • Katri Korpela

    (Immunobiology Research Program, University of Helsinki)

  • Anne Salonen

    (Immunobiology Research Program, University of Helsinki)

  • Lauri J. Virta

    (Social Insurance Institution)

  • Riina A. Kekkonen

    (Valio Limited)

  • Kristoffer Forslund

    (European Molecular Biology Laboratory)

  • Peer Bork

    (European Molecular Biology Laboratory)

  • Willem M. de Vos

    (Immunobiology Research Program, University of Helsinki
    University of Helsinki
    Laboratory of Microbiology, Wageningen University)

Abstract

Early-life antibiotic use is associated with increased risk for metabolic and immunological diseases, and mouse studies indicate a causal role of the disrupted microbiome. However, little is known about the impacts of antibiotics on the developing microbiome of children. Here we use phylogenetics, metagenomics and individual antibiotic purchase records to show that macrolide use in 2–7 year-old Finnish children (N=142; sampled at two time points) is associated with a long-lasting shift in microbiota composition and metabolism. The shift includes depletion of Actinobacteria, increase in Bacteroidetes and Proteobacteria, decrease in bile-salt hydrolase and increase in macrolide resistance. Furthermore, macrolide use in early life is associated with increased risk of asthma and predisposes to antibiotic-associated weight gain. Overweight and asthmatic children have distinct microbiota compositions. Penicillins leave a weaker mark on the microbiota than macrolides. Our results support the idea that, without compromising clinical practice, the impact on the intestinal microbiota should be considered when prescribing antibiotics.

Suggested Citation

  • Katri Korpela & Anne Salonen & Lauri J. Virta & Riina A. Kekkonen & Kristoffer Forslund & Peer Bork & Willem M. de Vos, 2016. "Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children," Nature Communications, Nature, vol. 7(1), pages 1-8, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10410
    DOI: 10.1038/ncomms10410
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    Cited by:

    1. Brandon Hickman & Anne Salonen & Alise J. Ponsero & Roosa Jokela & Kaija-Leena Kolho & Willem M. Vos & Katri Korpela, 2024. "Gut microbiota wellbeing index predicts overall health in a cohort of 1000 infants," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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