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Evolution of the fish heart by sub/neofunctionalization of an elastin gene

Author

Listed:
  • Yuuta Moriyama

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo)

  • Fumihiro Ito

    (National Institute of Genetics
    The Graduate University for Advanced Studies (SOKENDAI))

  • Hiroyuki Takeda

    (Graduate School of Science, The University of Tokyo)

  • Tohru Yano

    (The Jikei University School of Medicine)

  • Masataka Okabe

    (The Jikei University School of Medicine)

  • Shigehiro Kuraku

    (Phyloinformatics Unit, RIKEN Center for Life Science Technologies)

  • Fred W. Keeley

    (Research Institute, The Hospital for Sick Children
    University of Toronto)

  • Kazuko Koshiba-Takeuchi

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo
    Graduate School of Frontier Sciences, The University of Tokyo)

Abstract

The evolution of phenotypic traits is a key process in diversification of life. However, the mechanisms underlying the emergence of such evolutionary novelties are largely unknown. Here we address the origin of bulbus arteriosus (BA), an organ of evolutionary novelty seen in the teleost heart outflow tract (OFT), which sophisticates their circulatory system. The BA is a unique organ that is composed of smooth muscle while the OFTs in other vertebrates are composed of cardiac muscle. Here we reveal that the teleost-specific extracellular matrix (ECM) gene, elastin b, was generated by the teleost-specific whole-genome duplication and neofunctionalized to contribute to acquisition of the BA by regulating cell fate determination of cardiac precursor cells into smooth muscle. Furthermore, we show that the mechanotransducer yap is involved in this cell fate determination. Our findings reveal a mechanism of generating evolutionary novelty through alteration of cell fate determination by the ECM.

Suggested Citation

  • Yuuta Moriyama & Fumihiro Ito & Hiroyuki Takeda & Tohru Yano & Masataka Okabe & Shigehiro Kuraku & Fred W. Keeley & Kazuko Koshiba-Takeuchi, 2016. "Evolution of the fish heart by sub/neofunctionalization of an elastin gene," Nature Communications, Nature, vol. 7(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10397
    DOI: 10.1038/ncomms10397
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