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Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Author

Listed:
  • Slim Fourati

    (Vaccine and Gene Therapy Institute of Florida
    University Hospitals of Cleveland and Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA)

  • Razvan Cristescu

    (Merck Research Laboratories)

  • Andrey Loboda

    (Merck Research Laboratories)

  • Aarthi Talla

    (Vaccine and Gene Therapy Institute of Florida
    University Hospitals of Cleveland and Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA)

  • Ali Filali

    (Vaccine and Gene Therapy Institute of Florida
    University Hospitals of Cleveland and Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA)

  • Radha Railkar

    (Merck Research Laboratories)

  • Andrea K. Schaeffer

    (Merck Research Laboratories)

  • David Favre

    (Caprion/ImmuneCarta)

  • Dominic Gagnon

    (Caprion/ImmuneCarta)

  • Yoav Peretz

    (Caprion/ImmuneCarta)

  • I-Ming Wang

    (Merck Research Laboratories)

  • Chan R. Beals

    (Merck Research Laboratories)

  • Danilo R. Casimiro

    (Merck Research Laboratories)

  • Leonidas N. Carayannopoulos

    (Merck Research Laboratories)

  • Rafick-Pierre Sékaly

    (Vaccine and Gene Therapy Institute of Florida
    University Hospitals of Cleveland and Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA)

Abstract

Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Here we show, using transcriptional and cytometric profiling of whole blood collected before vaccination, that heightened expression of genes that augment B-cell responses and higher memory B-cell frequencies correlate with stronger responses to HBV vaccine. In contrast, higher levels of inflammatory response transcripts and increased frequencies of pro-inflammatory innate cells correlate with weaker responses to this vaccine. Increased numbers of erythrocytes and the haem-induced response also correlate with poor response to the HBV vaccine. A transcriptomics-based pre-vaccination predictor of response to HBV vaccine is built and validated in distinct sets of older adults. This moderately accurate (area under the curve≈65%) but robust signature is supported by flow cytometry and cytokine profiling. This study is the first that identifies baseline predictors and mechanisms of response to the HBV vaccine.

Suggested Citation

  • Slim Fourati & Razvan Cristescu & Andrey Loboda & Aarthi Talla & Ali Filali & Radha Railkar & Andrea K. Schaeffer & David Favre & Dominic Gagnon & Yoav Peretz & I-Ming Wang & Chan R. Beals & Danilo R., 2016. "Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination," Nature Communications, Nature, vol. 7(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10369
    DOI: 10.1038/ncomms10369
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    Cited by:

    1. Brad R Rosenberg & Marion Depla & Catherine A Freije & Denis Gaucher & Sabrina Mazouz & Maude Boisvert & Nathalie Bédard & Julie Bruneau & Charles M Rice & Naglaa H Shoukry, 2018. "Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection in patients with spontaneous viral clearance," PLOS Pathogens, Public Library of Science, vol. 14(9), pages 1-24, September.

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