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Two-dimensional honeycomb network through sequence-controlled self-assembly of oligopeptides

Author

Listed:
  • Sabine Abb

    (Max Planck Institute for Solid State Research)

  • Ludger Harnau
  • Rico Gutzler

    (Max Planck Institute for Solid State Research)

  • Stephan Rauschenbach

    (Max Planck Institute for Solid State Research)

  • Klaus Kern

    (Max Planck Institute for Solid State Research
    Institut de Physique de la Matière Condensée, Ecole Polytechnique Fédérale de Lausanne)

Abstract

The sequence of a peptide programs its self-assembly and hence the expression of specific properties through non-covalent interactions. A large variety of peptide nanostructures has been designed employing different aspects of these non-covalent interactions, such as dispersive interactions, hydrogen bonding or ionic interactions. Here we demonstrate the sequence-controlled fabrication of molecular nanostructures using peptides as bio-organic building blocks for two-dimensional (2D) self-assembly. Scanning tunnelling microscopy reveals changes from compact or linear assemblies (angiotensin I) to long-range ordered, chiral honeycomb networks (angiotensin II) as a result of removal of steric hindrance by sequence modification. Guided by our observations, molecular dynamic simulations yield atomistic models for the elucidation of interpeptide-binding motifs. This new approach to 2D self-assembly on surfaces grants insight at the atomic level that will enable the use of oligo- and polypeptides as large, multi-functional bio-organic building blocks, and opens a new route towards rationally designed, bio-inspired surfaces.

Suggested Citation

  • Sabine Abb & Ludger Harnau & Rico Gutzler & Stephan Rauschenbach & Klaus Kern, 2016. "Two-dimensional honeycomb network through sequence-controlled self-assembly of oligopeptides," Nature Communications, Nature, vol. 7(1), pages 1-7, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10335
    DOI: 10.1038/ncomms10335
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    Cited by:

    1. Xu Wu & Bogdana Borca & Suman Sen & Sebastian Koslowski & Sabine Abb & Daniel Pablo Rosenblatt & Aurelio Gallardo & Jesús I. Mendieta-Moreno & Matyas Nachtigall & Pavel Jelinek & Stephan Rauschenbach , 2023. "Molecular sensitised probe for amino acid recognition within peptide sequences," Nature Communications, Nature, vol. 14(1), pages 1-8, December.

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