IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms10321.html
   My bibliography  Save this article

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Author

Listed:
  • Charlotte L. Scott

    (Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
    Ghent University)

  • Fang Zheng

    (Myeloid Cell Immunology, VIB
    Cellular and Molecular Immunology Research Group, Vrije Universiteit Brussel
    Present Address: Department of Biochemistry and Molecular Biology, Health Science Center, Xi’an Jiaotong University, Xi’an 710049, China)

  • Patrick De Baetselier

    (Myeloid Cell Immunology, VIB
    Cellular and Molecular Immunology Research Group, Vrije Universiteit Brussel)

  • Liesbet Martens

    (Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
    Ghent University)

  • Yvan Saeys

    (Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
    Ghent University)

  • Sofie De Prijck

    (Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
    Ghent University)

  • Saskia Lippens

    (Ghent University
    VIB Bio Imaging Core
    Microscopy Core Facility, VIB, Inflammation Research Center)

  • Chloé Abels

    (Myeloid Cell Immunology, VIB
    Cellular and Molecular Immunology Research Group, Vrije Universiteit Brussel)

  • Steve Schoonooghe

    (Myeloid Cell Immunology, VIB
    Cellular and Molecular Immunology Research Group, Vrije Universiteit Brussel)

  • Geert Raes

    (Myeloid Cell Immunology, VIB
    Cellular and Molecular Immunology Research Group, Vrije Universiteit Brussel)

  • Nick Devoogdt

    (Cellular and Molecular Immunology Research Group, Vrije Universiteit Brussel
    In Vivo Cellular and Molecular Imaging Research Group, Vrije Universiteit Brussel)

  • Bart N. Lambrecht

    (Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
    Ghent University)

  • Alain Beschin

    (Myeloid Cell Immunology, VIB
    Cellular and Molecular Immunology Research Group, Vrije Universiteit Brussel)

  • Martin Guilliams

    (Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
    Ghent University)

Abstract

Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability and show that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells. Underlining the physiological relevance of our findings, circulating monocytes also contribute to the expanding pool of macrophages in the liver shortly after birth, when macrophage niches become available during normal organ growth. Thus, like embryonic precursors, monocytes can and do give rise to self-renewing tissue-resident macrophages if the niche is available to them.

Suggested Citation

  • Charlotte L. Scott & Fang Zheng & Patrick De Baetselier & Liesbet Martens & Yvan Saeys & Sofie De Prijck & Saskia Lippens & Chloé Abels & Steve Schoonooghe & Geert Raes & Nick Devoogdt & Bart N. Lambr, 2016. "Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells," Nature Communications, Nature, vol. 7(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10321
    DOI: 10.1038/ncomms10321
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms10321
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms10321?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Stacy K. Thomas & Max M. Wattenberg & Shaanti Choi-Bose & Mark Uhlik & Ben Harrison & Heather Coho & Christopher R. Cassella & Meredith L. Stone & Dhruv Patel & Kelly Markowitz & Devora Delman & Micha, 2023. "Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Franziska Hildebrandt & Alma Andersson & Sami Saarenpää & Ludvig Larsson & Noémi Van Hul & Sachie Kanatani & Jan Masek & Ewa Ellis & Antonio Barragan & Annelie Mollbrink & Emma R. Andersson & Joakim L, 2021. "Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Inhye Park & Michael E. Goddard & Jennifer E. Cole & Natacha Zanin & Leo-Pekka Lyytikäinen & Terho Lehtimäki & Evangelos Andreakos & Marc Feldmann & Irina Udalova & Ignat Drozdov & Claudia Monaco, 2022. "C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10321. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.