IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms10248.html
   My bibliography  Save this article

Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles

Author

Listed:
  • Frederick S. Varn

    (Geisel School of Medicine at Dartmouth)

  • Erik H. Andrews

    (Geisel School of Medicine at Dartmouth)

  • David W. Mullins

    (Geisel School of Medicine at Dartmouth
    Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth)

  • Chao Cheng

    (Geisel School of Medicine at Dartmouth
    Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth
    Institute for Quantitative Biomedical Sciences, Geisel School of Medicine at Dartmouth)

Abstract

Transcriptional programmes active in haematopoietic cells enable a variety of functions including dedifferentiation, innate immunity and adaptive immunity. Understanding how these programmes function in the context of cancer can provide valuable insights into host immune response, cancer severity and potential therapy response. Here we present a method that uses the transcriptomes of over 200 murine haematopoietic cells, to infer the lineage-specific haematopoietic activity present in human breast tumours. Correlating this activity with patient survival and tumour purity reveals that the transcriptional programmes of many cell types influence patient prognosis and are found in environments of high lymphocytic infiltration. Collectively, these results allow for a detailed and personalized assessment of the patient immune response to a tumour. When combined with routinely collected patient biopsy genomic data, this method can enable a richer understanding of the complex interplay between the host immune system and cancer.

Suggested Citation

  • Frederick S. Varn & Erik H. Andrews & David W. Mullins & Chao Cheng, 2016. "Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles," Nature Communications, Nature, vol. 7(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10248
    DOI: 10.1038/ncomms10248
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms10248
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms10248?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10248. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.