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Bio-recognitive photonics of a DNA-guided organic semiconductor

Author

Listed:
  • Seung Hyuk Back

    (KU-KIST Graduate School of Converging Science and Technology, Korea University)

  • Jin Hyuk Park

    (Korea University)

  • Chunzhi Cui

    (Korea University)

  • Dong June Ahn

    (KU-KIST Graduate School of Converging Science and Technology, Korea University
    Korea University
    Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology)

Abstract

Incorporation of duplex DNA with higher molecular weights has attracted attention for a new opportunity towards a better organic light-emitting diode (OLED) capability. However, biological recognition by OLED materials is yet to be addressed. In this study, specific oligomeric DNA–DNA recognition is successfully achieved by tri (8-hydroxyquinoline) aluminium (Alq3), an organic semiconductor. Alq3 rods crystallized with guidance from single-strand DNA molecules show, strikingly, a unique distribution of the DNA molecules with a shape of an ‘inverted’ hourglass. The crystal’s luminescent intensity is enhanced by 1.6-fold upon recognition of the perfect-matched target DNA sequence, but not in the case of a single-base mismatched one. The DNA–DNA recognition forming double-helix structure is identified to occur only in the rod’s outer periphery. This study opens up new opportunities of Alq3, one of the most widely used OLED materials, enabling biological recognition.

Suggested Citation

  • Seung Hyuk Back & Jin Hyuk Park & Chunzhi Cui & Dong June Ahn, 2016. "Bio-recognitive photonics of a DNA-guided organic semiconductor," Nature Communications, Nature, vol. 7(1), pages 1-6, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10234
    DOI: 10.1038/ncomms10234
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    Cited by:

    1. Woo Hyuk Jung & Jin Hyuk Park & Seokho Kim & Chunzhi Cui & Dong June Ahn, 2022. "Molecular doping of nucleic acids into light emitting crystals driven by multisite-intermolecular interaction," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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