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Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity

Author

Listed:
  • Victor Laurent

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Adrien Guérard

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Catherine Mazerolles

    (Institut Universitaire du Cancer)

  • Sophie Le Gonidec

    (Université de Toulouse, UPS
    Obésité et Diabète”, Institut National de la Santé et de la Recherche Médicale)

  • Aurélie Toulet

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Laurence Nieto

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Falek Zaidi

    (Institut Universitaire du Cancer)

  • Bilal Majed

    (Centre Hospitalier de la Région de Saint-Omer (CHRSO), Route de Blendecques)

  • David Garandeau

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Youri Socrier

    (Institut Universitaire du Cancer)

  • Muriel Golzio

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Thomas Cadoudal

    (Université de Toulouse, UPS
    Obésité et Diabète”, Institut National de la Santé et de la Recherche Médicale)

  • Karima Chaoui

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Cedric Dray

    (Université de Toulouse, UPS
    Obésité et Diabète”, Institut National de la Santé et de la Recherche Médicale)

  • Bernard Monsarrat

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Odile Schiltz

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Yuan Yuan Wang

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

  • Bettina Couderc

    (Université de Toulouse, UPS
    Centre de Recherche en Cancérologie de Toulouse (CRCT))

  • Philippe Valet

    (Université de Toulouse, UPS
    Obésité et Diabète”, Institut National de la Santé et de la Recherche Médicale)

  • Bernard Malavaud

    (Université de Toulouse, UPS
    Institut Universitaire du Cancer)

  • Catherine Muller

    (Université de Toulouse, UPS
    CNRS; Institut de Pharmacologie et de Biologie Structurale
    Institut de Pharmacologie et de Biologie Structurale)

Abstract

Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This process is dependent on the secretion of the chemokine CCL7 by adipocytes, which diffuses from PPAT to the peripheral zone of the prostate, stimulating the migration of CCR3 expressing tumour cells. In obesity, higher secretion of CCL7 by adipocytes facilitates extraprostatic extension. The observed increase in migration associated with obesity is totally abrogated when the CCR3/CCL7 axis is inhibited. In human prostate cancer tumours, expression of the CCR3 receptor is associated with the occurrence of aggressive disease with extended local dissemination and a higher risk of biochemical recurrence, highlighting the potential benefit of CCR3 antagonists in the treatment of prostate cancer.

Suggested Citation

  • Victor Laurent & Adrien Guérard & Catherine Mazerolles & Sophie Le Gonidec & Aurélie Toulet & Laurence Nieto & Falek Zaidi & Bilal Majed & David Garandeau & Youri Socrier & Muriel Golzio & Thomas Cado, 2016. "Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity," Nature Communications, Nature, vol. 7(1), pages 1-15, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10230
    DOI: 10.1038/ncomms10230
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