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Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius

Author

Listed:
  • Jeffrey A. Rosenfeld

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History
    Cancer Institute of New Jersey, Rutgers University)

  • Darryl Reeves

    (Weill Cornell Medical College
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine
    Tri-Institutional Training Program in Computational Biology and Medicine)

  • Mercer R. Brugler

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History
    NYC College of Technology (CUNY))

  • Apurva Narechania

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History)

  • Sabrina Simon

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    Biosystematics, Wageningen University)

  • Russell Durrett

    (Weill Cornell Medical College
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine)

  • Jonathan Foox

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History)

  • Kevin Shianna

    (Illumina Inc. 5200 Illumina Way)

  • Michael C. Schatz

    (Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory)

  • Jorge Gandara

    (Weill Cornell Medical College
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine)

  • Ebrahim Afshinnekoo

    (Weill Cornell Medical College
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine)

  • Ernest T. Lam

    (BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100)

  • Alex R. Hastie

    (BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100)

  • Saki Chan

    (BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100)

  • Han Cao

    (BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100)

  • Michael Saghbini

    (BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100)

  • Alex Kentsis

    (Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, Cornell University)

  • Paul J. Planet

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History
    College of Physicians and Surgeons, Columbia University)

  • Vladyslav Kholodovych

    (High Performance and Research Computing Group, Rutgers Biomedical and Health Sciences)

  • Michael Tessler

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History)

  • Richard Baker

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History)

  • Rob DeSalle

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History)

  • Louis N. Sorkin

    (American Museum of Natural History)

  • Sergios-Orestis Kolokotronis

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History
    Fordham University)

  • Mark E. Siddall

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History)

  • George Amato

    (Sackler Institute for Comparative Genomics, American Museum of Natural History
    American Museum of Natural History)

  • Christopher E. Mason

    (Weill Cornell Medical College
    The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine
    Tri-Institutional Training Program in Computational Biology and Medicine
    The Feil Family Brain and Mind Research Institute)

Abstract

The common bed bug (Cimex lectularius) has been a persistent pest of humans for thousands of years, yet the genetic basis of the bed bug’s basic biology and adaptation to dense human environments is largely unknown. Here we report the assembly, annotation and phylogenetic mapping of the 697.9-Mb Cimex lectularius genome, with an N50 of 971 kb, using both long and short read technologies. A RNA-seq time course across all five developmental stages and male and female adults generated 36,985 coding and noncoding gene models. The most pronounced change in gene expression during the life cycle occurs after feeding on human blood and included genes from the Wolbachia endosymbiont, which shows a simultaneous and coordinated host/commensal response to haematophagous activity. These data provide a rich genetic resource for mapping activity and density of C. lectularius across human hosts and cities, which can help track, manage and control bed bug infestations.

Suggested Citation

  • Jeffrey A. Rosenfeld & Darryl Reeves & Mercer R. Brugler & Apurva Narechania & Sabrina Simon & Russell Durrett & Jonathan Foox & Kevin Shianna & Michael C. Schatz & Jorge Gandara & Ebrahim Afshinnekoo, 2016. "Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius," Nature Communications, Nature, vol. 7(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10164
    DOI: 10.1038/ncomms10164
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