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Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes

Author

Listed:
  • Hernan Lorenzi

    (The J. Craig Venter Institute, 9704 Medical Center Drive)

  • Asis Khan

    (Washington University School of Medicine
    Laboratory of Parasitic Diseases, NIAID, National Institutes of Health)

  • Michael S. Behnke

    (Washington University School of Medicine
    Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University)

  • Sivaranjani Namasivayam

    (University of Georgia
    Center for Tropical and Emerging Global Diseases, University of Georgia)

  • Lakshmipuram S. Swapna

    (Program in Molecular Structure and Function, Hospital for Sick Children
    University of Toronto)

  • Michalis Hadjithomas

    (The J. Craig Venter Institute, 9704 Medical Center Drive
    Present address: Prokaryotic Super Program, DOE Joint Genome Institute, Walnut Creek, California 94598, USA.)

  • Svetlana Karamycheva

    (The J. Craig Venter Institute, 9704 Medical Center Drive)

  • Deborah Pinney

    (University of Pennsylvania)

  • Brian P. Brunk

    (University of Pennsylvania)

  • James W. Ajioka

    (University of Cambridge)

  • Daniel Ajzenberg

    (Biological Resource Center for Toxoplasma, INSERM, University Limoges, CHU Limoges, UMR_S 1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology)

  • John C. Boothroyd

    (Stanford School of Medicine)

  • Jon P. Boyle

    (Dietrich School of Arts and Sciences, University of Pittsburgh
    Pennsylvania)

  • Marie L. Dardé

    (Biological Resource Center for Toxoplasma, INSERM, University Limoges, CHU Limoges, UMR_S 1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology)

  • Maria A. Diaz-Miranda

    (University of Pennsylvania)

  • Jitender P. Dubey

    (Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA)

  • Heather M. Fritz

    (Washington State University, College of Veterinary Medicine)

  • Solange M. Gennari

    (Faculty of Veterinary Medicine, University of São Paulo)

  • Brian D. Gregory

    (University of Pennsylvania)

  • Kami Kim

    (Pathology, and Microbiology and Immunology, Albert Einstein College of Medicine)

  • Jeroen P. J. Saeij

    (Microbiology & Immunology, University of California)

  • Chunlei Su

    (University of Tennessee)

  • Michael W. White

    (Florida Center for Drug Discovery and Development (CDDI), University of South Florida)

  • Xing-Quan Zhu

    (State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences)

  • Daniel K. Howe

    (University of Kentucky)

  • Benjamin M. Rosenthal

    (Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA)

  • Michael E. Grigg

    (Laboratory of Parasitic Diseases, NIAID, National Institutes of Health)

  • John Parkinson

    (Program in Molecular Structure and Function, Hospital for Sick Children
    University of Toronto)

  • Liang Liu

    (University of Georgia
    Institute of Bioinformatics, University of Georgia)

  • Jessica C. Kissinger

    (University of Georgia
    Center for Tropical and Emerging Global Diseases, University of Georgia
    Institute of Bioinformatics, University of Georgia)

  • David S. Roos

    (University of Pennsylvania)

  • L. David Sibley

    (Washington University School of Medicine)

Abstract

Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild and domestic animals and causing zoonotic infections in humans. T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges. To elucidate the genetic basis for these differences, we compared the genomes of 62 globally distributed T. gondii isolates to several closely related coccidian parasites. Our findings reveal that tandem amplification and diversification of secretory pathogenesis determinants is the primary feature that distinguishes the closely related genomes of these biologically diverse parasites. We further show that the unusual population structure of T. gondii is characterized by clade-specific inheritance of large conserved haploblocks that are significantly enriched in tandemly clustered secretory pathogenesis determinants. The shared inheritance of these conserved haploblocks, which show a different ancestry than the genome as a whole, may thus influence transmission, host range and pathogenicity.

Suggested Citation

  • Hernan Lorenzi & Asis Khan & Michael S. Behnke & Sivaranjani Namasivayam & Lakshmipuram S. Swapna & Michalis Hadjithomas & Svetlana Karamycheva & Deborah Pinney & Brian P. Brunk & James W. Ajioka & Da, 2016. "Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes," Nature Communications, Nature, vol. 7(1), pages 1-13, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10147
    DOI: 10.1038/ncomms10147
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    Cited by:

    1. Jingjing Lou & Yasaman Rezvani & Argenis Arriojas & Yihan Wu & Nachiket Shankar & David Degras & Caroline D. Keroack & Manoj T. Duraisingh & Kourosh Zarringhalam & Marc-Jan Gubbels, 2024. "Single cell expression and chromatin accessibility of the Toxoplasma gondii lytic cycle identifies AP2XII-8 as an essential ribosome regulon driver," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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