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Ciliated neurons lining the central canal sense both fluid movement and pH through ASIC3

Author

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  • Elham Jalalvand

    (The Nobel Institute for Neurophysiology, Karolinska Institutet)

  • Brita Robertson

    (The Nobel Institute for Neurophysiology, Karolinska Institutet)

  • Peter Wallén

    (The Nobel Institute for Neurophysiology, Karolinska Institutet)

  • Sten Grillner

    (The Nobel Institute for Neurophysiology, Karolinska Institutet)

Abstract

Cerebrospinal fluid-contacting (CSF-c) cells are found in all vertebrates but their function has remained elusive. We recently identified one type of laterally projecting CSF-c cell in lamprey spinal cord with neuronal properties that expresses GABA and somatostatin. We show here that these CSF-c neurons respond to both mechanical stimulation and to lowered pH. These effects are most likely mediated by ASIC3-channels, since APETx2, a specific antagonist of ASIC3, blocks them both. Furthermore, lowering of pH as well as application of somatostatin will reduce the locomotor burst rate. The somatostatin receptor antagonist counteracts the effects of both a decrease in pH and of somatostatin. Lateral bending movement imposed on the spinal cord, as would occur during natural swimming, activates CSF-c neurons. Taken together, we show that CSF-c neurons act both as mechanoreceptors and as chemoreceptors through ASIC3 channels, and their action may protect against pH-changes resulting from excessive neuronal activity.

Suggested Citation

  • Elham Jalalvand & Brita Robertson & Peter Wallén & Sten Grillner, 2016. "Ciliated neurons lining the central canal sense both fluid movement and pH through ASIC3," Nature Communications, Nature, vol. 7(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10002
    DOI: 10.1038/ncomms10002
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