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Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light

Author

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  • Haowen Ruan

    (California Institute of Technology)

  • Mooseok Jang

    (California Institute of Technology)

  • Changhuei Yang

    (California Institute of Technology)

Abstract

Focusing light inside scattering media in a freely addressable fashion is challenging, as the wavefront of the scattered light is highly disordered. Recently developed ultrasound-guided wavefront shaping methods are addressing this challenge, albeit with relatively low modulation efficiency and resolution limitations. In this paper, we present a new technique, time-reversed ultrasound microbubble encoded (TRUME) optical focusing, which can focus light with improved efficiency and sub-ultrasound wavelength resolution. This method ultrasonically destroys microbubbles, and measures the wavefront change to compute and render a suitable time-reversed wavefront solution for focusing. We demonstrate that the TRUME technique can create an optical focus at the site of bubble destruction with a size of ∼2 μm. We further demonstrate a twofold enhancement in addressable focus resolution in a microbubble aggregate target by exploiting the nonlinear pressure-to-destruction response of the microbubbles. The reported technique provides a deep tissue-focusing solution with high efficiency, resolution, and specificity.

Suggested Citation

  • Haowen Ruan & Mooseok Jang & Changhuei Yang, 2015. "Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light," Nature Communications, Nature, vol. 6(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9968
    DOI: 10.1038/ncomms9968
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    Cited by:

    1. Seonghee Cho & Minsu Kim & Joongho Ahn & Yeonggeun Kim & Junha Lim & Jeongwoo Park & Hyung Ham Kim & Won Jong Kim & Chulhong Kim, 2024. "An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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