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Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection

Author

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  • Yuanhui Zheng

    (School of Chemistry, The University of New South Wales
    Australian Centre for NanoMedicine, The University of New South Wales
    ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales)

  • Alexander H. Soeriyadi

    (School of Chemistry, The University of New South Wales
    Australian Centre for NanoMedicine, The University of New South Wales
    ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales)

  • Lorenzo Rosa

    (Centre for Micro-Photonics (H34), Swinburne University of Technology
    University of Parma)

  • Soon Hock Ng

    (Monash University
    The Melbourne Centre for Nanofabrication)

  • Udo Bach

    (Monash University
    The Melbourne Centre for Nanofabrication)

  • J. Justin Gooding

    (School of Chemistry, The University of New South Wales
    Australian Centre for NanoMedicine, The University of New South Wales
    ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales)

Abstract

Single-molecule surface-enhanced Raman spectroscopy (SERS) has attracted increasing interest for chemical and biochemical sensing. Many conventional substrates have a broad distribution of SERS enhancements, which compromise reproducibility and result in slow response times for single-molecule detection. Here we report a smart plasmonic sensor that can reversibly trap a single molecule at hotspots for rapid single-molecule detection. The sensor was fabricated through electrostatic self-assembly of gold nanoparticles onto a gold/silica-coated silicon substrate, producing a high yield of uniformly distributed hotspots on the surface. The hotspots were isolated with a monolayer of a thermoresponsive polymer (poly(N-isopropylacrylamide)), which act as gates for molecular trapping at the hotspots. The sensor shows not only a good SERS reproducibility but also a capability to repetitively trap and release molecules for single-molecular sensing. The single-molecule sensitivity is experimentally verified using SERS spectral blinking and bianalyte methods.

Suggested Citation

  • Yuanhui Zheng & Alexander H. Soeriyadi & Lorenzo Rosa & Soon Hock Ng & Udo Bach & J. Justin Gooding, 2015. "Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection," Nature Communications, Nature, vol. 6(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9797
    DOI: 10.1038/ncomms9797
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