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Targeted drug delivery using genetically engineered diatom biosilica

Author

Listed:
  • Bahman Delalat

    (ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes Boulevard, Mawson Lakes, South Australia 5095, Australia)

  • Vonda C. Sheppard

    (School of Chemistry and Biochemistry, Georgia Institute of Technology)

  • Soraya Rasi Ghaemi

    (ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes Boulevard, Mawson Lakes, South Australia 5095, Australia)

  • Shasha Rao

    (School of Pharmacy and Medical Sciences , University of South Australia)

  • Clive A. Prestidge

    (School of Pharmacy and Medical Sciences , University of South Australia)

  • Gordon McPhee

    (ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes Boulevard, Mawson Lakes, South Australia 5095, Australia)

  • Mary-Louise Rogers

    (Centre for Neuroscience, Flinders University)

  • Jacqueline F. Donoghue

    (Oncogenic Signalling Laboratory and Brain Cancer Discovery Collaborative, Centre for Cancer Research, Hudson Institute of Medical Research
    Monash University)

  • Vinochani Pillay

    (Oncogenic Signalling Laboratory and Brain Cancer Discovery Collaborative, Centre for Cancer Research, Hudson Institute of Medical Research
    Monash University)

  • Terrance G. Johns

    (Oncogenic Signalling Laboratory and Brain Cancer Discovery Collaborative, Centre for Cancer Research, Hudson Institute of Medical Research
    Monash University)

  • Nils Kröger

    (School of Chemistry and Biochemistry, Georgia Institute of Technology
    B CUBE Centre for Molecular Bioengineering, TU Dresden
    TU Dresden)

  • Nicolas H. Voelcker

    (ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes Boulevard, Mawson Lakes, South Australia 5095, Australia)

Abstract

The ability to selectively kill cancerous cell populations while leaving healthy cells unaffected is a key goal in anticancer therapeutics. The use of nanoporous silica-based materials as drug-delivery vehicles has recently proven successful, yet production of these materials requires costly and toxic chemicals. Here we use diatom microalgae-derived nanoporous biosilica to deliver chemotherapeutic drugs to cancer cells. The diatom Thalassiosira pseudonana is genetically engineered to display an IgG-binding domain of protein G on the biosilica surface, enabling attachment of cell-targeting antibodies. Neuroblastoma and B-lymphoma cells are selectively targeted and killed by biosilica displaying specific antibodies sorbed with drug-loaded nanoparticles. Treatment with the same biosilica leads to tumour growth regression in a subcutaneous mouse xenograft model of neuroblastoma. These data indicate that genetically engineered biosilica frustules may be used as versatile ‘backpacks’ for the targeted delivery of poorly water-soluble anticancer drugs to tumour sites.

Suggested Citation

  • Bahman Delalat & Vonda C. Sheppard & Soraya Rasi Ghaemi & Shasha Rao & Clive A. Prestidge & Gordon McPhee & Mary-Louise Rogers & Jacqueline F. Donoghue & Vinochani Pillay & Terrance G. Johns & Nils Kr, 2015. "Targeted drug delivery using genetically engineered diatom biosilica," Nature Communications, Nature, vol. 6(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9791
    DOI: 10.1038/ncomms9791
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    Cited by:

    1. Liu, Peng & Liu, Xijun, 2017. "Dynamics of a tumor-immune model considering targeted chemotherapy," Chaos, Solitons & Fractals, Elsevier, vol. 98(C), pages 7-13.

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